Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread.
Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread.
复制标题
病毒相关的粘膜上皮紧密连接破坏及其在病毒传播和扩散中的作用。
DOI：
10.1080/21688370.2021.1943274
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发表时间：
2021
期刊：
影响因子：
3.1
通讯作者：
Tugizov,Sharof
中科院分区：
文献类型：
--
作者：
Tugizov,Sharof
口咽、呼吸道、肠道和生殖器粘膜上皮是大多数人类致病病毒进入的主要途径。要发起全身性感染，病毒必须首先通过粘膜上皮传播，然后在全身传播。然而，粘膜上皮具有发达的紧密连接，具有很强的屏障功能，在防止病毒病原体的传播和传播中起着至关重要的作用。病毒可以通过破坏粘膜上皮的紧密连接来克服这些障碍，粘膜上皮的紧密连接促进了细胞旁病毒的渗透，并引发了全身性疾病。紧密和粘连连接的破坏也可能释放连接区域内隔离的病毒受体，隐藏的受体的释放可能促进粘膜上皮细胞的病毒感染。本文就病毒相关的粘膜上皮连接破坏的可能分子机制及其在病毒跨粘膜传播和扩散中的作用作一综述。
Oropharyngeal, airway, intestinal, and genital mucosal epithelia are the main portals of entry for the majority of human pathogenic viruses. To initiate systemic infection, viruses must first be transmitted across the mucosal epithelium and then spread across the body. However, mucosal epithelia have well-developed tight junctions, which have a strong barrier function that plays a critical role in preventing the spread and dissemination of viral pathogens. Viruses can overcome these barriers by disrupting the tight junctions of mucosal epithelia, which facilitate paracellular viral penetration and initiate systemic disease. Disruption of tight and adherens junctions may also release the sequestered viral receptors within the junctional areas, and liberation of hidden receptors may facilitate viral infection of mucosal epithelia. This review focuses on possible molecular mechanisms of virus-associated disruption of mucosal epithelial junctions and its role in transmucosal viral transmission and spread.