2′-5′-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1
2′-5′-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1
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DOI：
10.1128/jvi.01076-15
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发表时间：
2015-10-01
影响因子：
5.4
通讯作者：
Barik, Sailen
中科院分区：
文献类型：
--
作者：
Dhar, Jayeeta;Cuevas, Rolando A.;Barik, Sailen
2‘-5’-寡腺苷合成酶样蛋白(OASL)是一种干扰素诱导的抗病毒蛋白。在这里，我们描述了人OASL和两个小鼠OASL同系物对呼吸道合胞病毒(RSV)复制的不同抑制活性。有趣的是，RSV的非结构蛋白1(NS1)促进了特定OASL亚型的蛋白酶体依赖的降解。我们得出结论，OASL作为一种细胞抗病毒蛋白发挥作用，RSV NS1抑制这一功能以逃避细胞天然免疫并允许病毒生长。
2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome-dependent degradation of specific OASL isoforms. We conclude that OASL acts as a cellular antiviral protein and that RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.