Sheddable coatings for long-circulating nanoparticles.
Sheddable coatings for long-circulating nanoparticles.
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可用于长循环纳米颗粒的可覆盖涂料。
DOI：
10.1007/s11095-007-9348-7
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发表时间：
2008-01
影响因子：
3.7
通讯作者：
Storm, Gert
中科院分区：
文献类型：
--
作者：
Romberg, Birgit;Hennink, Wim E.;Storm, Gert
纳米粒子，如脂质体、聚合物胶束、脂质复合物和聚合物复合物，经常被作为靶向药物载体系统进行研究。这些粒子在血液中长时间循环的能力通常是成功靶向递送的先决条件。为了实现这一点，亲水性“隐形”聚合物，如聚乙二醇（PEG），被用作涂层材料。这类聚合物遮蔽粒子表面，从而减少血液蛋白的调理作用以及单核吞噬细胞系统中巨噬细胞的摄取。然而，在定位到病理部位后，纳米粒子应以有效的方式释放其内容物以实现足够的治疗反应。但是，聚合物涂层可能会阻碍药物释放和与靶细胞的相互作用，因此可能成为实现治疗反应的障碍。人们已经尝试通过脱落的方式，即到达靶部位后涂层消失，来提高空间稳定纳米粒子的治疗功效。这样的“去遮蔽”过程可能会促进药物释放和/或靶细胞相互作用过程。本综述概述了有关为制备空间稳定纳米颗粒而研究的不同脱落策略的文献。描述了已使用的脱离机制和刺激因素。
Nanoparticles, such as liposomes, polymeric micelles, lipoplexes and polyplexes are frequently studied as targeted drug carrier systems. The ability of these particles to circulate in the bloodstream for a prolonged period of time is often a prerequisite for successful targeted delivery. To achieve this, hydrophilic ‘stealth’ polymers, such as poly(ethylene glycol) (PEG), are used as coating materials. Such polymers shield the particle surface and thereby reduce opsonization by blood proteins and uptake by macrophages of the mononuclear phagocyte system. Yet, after localizing in the pathological site, nanoparticles should deliver their contents in an efficient manner to achieve a sufficient therapeutic response. The polymer coating, however, may hinder drug release and target cell interaction and can therefore be an obstacle in the realization of the therapeutic response. Attempts have been made to enhance the therapeutic efficacy of sterically stabilized nanoparticles by means of shedding, i.e. a loss of the coating after arrival at the target site. Such an ‘unmasking’ process may facilitate drug release and/or target cell interaction processes. This review presents an overview of the literature regarding different shedding strategies that have been investigated for the preparation of sterically stabilized nanoparticulates. Detach mechanisms and stimuli that have been used are described.
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影响因子：
3.4
作者：
ALLEN, TM;BRANDEIS, E;ZALIPSKY, S
通讯作者：
ZALIPSKY, S
影响因子：
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作者：
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作者：
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15
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AHMAD, M;BERGSTROM, RG;POWELL, MF
通讯作者：
POWELL, MF