Induction of skin allograft tolerance during metamorphosis of the toad xenopus laevis: a possible model for studying generation of self tolerance to histocompatibility antigens
Induction of skin allograft tolerance during metamorphosis of the toad xenopus laevis: a possible model for studying generation of self tolerance to histocompatibility antigens
复制标题
蟾蜍变态过程中皮肤同种异体移植耐受性的诱导：研究组织相容性抗原自身耐受性产生的可能模型
DOI：
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发表时间：
1973
影响因子：
5.4
通讯作者：
L. Pasquier
中科院分区：
文献类型：
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作者：
X. Chardonnens;L. Pasquier
从变态前15天到变态后60天，同种异体皮肤移植可以诱导爪蟾个体间对同种异体皮肤移植的免疫特异性耐受。组织相容性抗原的遗传决定了变态期间的耐受程度：在第一代的个体中，25- 50%的同胞是耐受的。在第二代个体中，当亲本在变态时对同种异体皮肤移植表现出相互耐受时，耐受百分比为75- 100%，而当亲本不相容时，耐受百分比仅为25%。鉴于这种耐受性的特点，我们认为它主要涉及弱组织相容性抗原，并且优先发生在变态阶段，因为在这个阶段，动物对许多新的自身抗原变得耐受。
From 15 days before to 60 days after metamorphosis, an immunologically specific tolerance to skin allografts between individuals of Xenopus can be induced by skin allografts. Genetic inheritance of histocompatibility antigens determines the degree of tolerance during metamorphosis: in individuals from the first generation, 25–50 % of the siblings were tolerant. In second generation individuals, the percentage of tolerance is 75–100 % when the parents show mutual tolerance to skin allografts at metamorphosis and only 25 % when the parents are mutually incompatible. In view of the characteristics of this tolerance it is suggested that it concerns mainly weak histocompatibility antigens and that it occurs preferentially at metamorphosis, as at this stage the animal becomes tolerant to many new self‐antigens.