THE ANTI-AGGREGATING PROPERTIES OF VASCULAR ENDOTHELIUM - INTERACTIONS BETWEEN PROSTACYCLIN AND NITRIC-OXIDE
THE ANTI-AGGREGATING PROPERTIES OF VASCULAR ENDOTHELIUM - INTERACTIONS BETWEEN PROSTACYCLIN AND NITRIC-OXIDE
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DOI：
10.1111/j.1476-5381.1987.tb11367.x
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发表时间：
1987-11-01
影响因子：
7.3
通讯作者：
MONCADA, S
中科院分区：
文献类型：
--
作者：
RADOMSKI, MW;PALMER, RMJ;MONCADA, S
1 The interactions between endothelium-derived nitric oxide (NO) and prostacyclin as inhibitors of platelet aggregation were examined. 2 Porcine aortic endothelial cells treated with indomethacin and stimulated with bradykinin (10-100 nM) released NO in quantities sufficient to account for the inhibition of platelet aggregation attributed to endothelium-derived relaxing factor (EDRF). 3 In the absence of indomethacin, stimulation of the cells with bradykinin (1-3 nM) released small amounts of prostacyclin and EDRF which synergistically inhibited platelet aggregation. 4 EDRF and authenic NO also caused disaggregation of platelets aggregated either with collagen or with U46619. 5 A reciprocal potentiation of both the anti- and the dis-aggregating activity was also observed between low concentrations of prostacyclin and authenic NO or EDRF released from endothelial cells. 6 It is likely that interactions between prostacyclin and NO released by the endothelium play a role in the homeostatic regulation of platelet-vessel wall interactions.
