INCREASE IN PERFORANT PATH QUANTAL SIZE IN AGED F344 RATS
INCREASE IN PERFORANT PATH QUANTAL SIZE IN AGED F344 RATS
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DOI：
10.1016/0197-4580(91)90071-q
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发表时间：
1991-09-01
影响因子：
4.2
通讯作者：
MCNAUGHTON, BL
中科院分区：
文献类型：
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作者：
FOSTER, TC;BARNES, CA;MCNAUGHTON, BL
这里提供的数据证实并扩展了在老年F-344大鼠海马区颗粒细胞上有较少但更强的穿透路径突触连接的证据。本报告中使用的老动物来自一个在Morris水任务中表现出对空间问题保持能力不足的种群。用微刺激穿支路传入的方法，发现25月龄的单个颗粒细胞EPSP大于6月龄和9月龄组。此外，应用统计方法进行量化分析，提供的数据表明，老年大鼠更大的突触反应是通过增加量子大小来实现的。因此，这些实验表明，单个突触在老年大鼠的穿支通路中变得更加强大，这种加强是通过增加量子大小来实现的。讨论了这些发现对海马区信息处理的意义。
The data presented here confirm and extend the evidence for fewer, but stronger, perforant path synaptic connections onto the granule cells of the hippocampus in old F-344 rats. The old animals used in the present report were drawn from a population that showed deficits in the retention of a spatial problem in the Morris water task. Using the method of minimal-stimulation of perforant path afferents, unitary granule cell EPSPs were found to be larger in the 25-month than in the 6- and 9-month age groups. Furthermore, applying statistical methods for quantal analysis, data are presented that suggest that the larger synaptic responses of the old rats come about through an increase in quantal size. These experiments therefore suggest that individual synapses become more powerful in the perforant pathway of old rats, and that this strengthening occurs through an increase in quantal size. The implications of these findings for hippocampal information processing are discussed.