Cardiac tissue engineering using stem cells.
Cardiac tissue engineering using stem cells.
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DOI：
10.1109/memb.2009.931792
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Bursac N
中科院分区：
文献类型：
--
作者：
Bursac N
干细胞注射治疗心肌梗死的有限临床成功主要归因于注射细胞的低保留和存活。用于提高细胞递送效率的替代方法包括以下：1）注射生物活性水凝胶和细胞的混合物，然后原位进行细胞-水凝胶聚合，和2）组织工程化心脏贴片的心外膜植入。虽然手术比细胞或细胞-水凝胶注射更复杂，但也预期贴片植入会提高递送细胞的存活率，并可能在梗死部位进行更有效的结构和功能组织重建。
The limited clinical success of stem-cell injections for the treatment of myocardial infarction has been mainly attributed to the low retention and survival of injected cells. Alternative methods for improving the efficiency of cell delivery include the following: 1) injection of a mixture of bioactive hydrogels and cells followed by cell-hydrogel polymerization in situ and 2) the epicardial implantation of a tissue-engineered cardiac patch. Although surgically more complex than cell or cell-hydrogel injection, the patch implantation is also expected to yield improved survival of delivered cells, and potentially, a more efficient structural and functional tissue reconstruction at the infarct site.