Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.
Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.
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DOI：
10.1002/adma.202108389
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发表时间：
2022-06
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眼睛是人体最复杂的器官之一，包含丰富而关键的生理信息(如眼压、角膜温度和pH值)以及代谢物生物标志物的库(如葡萄糖、蛋白质和特定离子)。智能隐形眼镜(SCLS)可以作为一种可穿戴的智能义眼装置，能够无创地连续监测各种基本的物理/生化参数和药物的加载/释放，用于眼科疾病的治疗。SCL技术的进步和公众对个性化健康日益增长的兴趣比以往任何时候都更加速了SCL的研究。本文通过对自组装材料从制造到应用再到商业化的全面综述，讨论了自组装材料的发展现状和潜力。首先，讨论了用于诊断和治疗应用的SCLS的材料、制造和平台设计。然后，综述了临床翻译中诊断和治疗SCLS的最新进展。然后，总结了目前应用于SCL设备的可穿戴式电能传输和无线数据传输技术。展望了下一代SCL器件的发展前景、未来的机遇和挑战。随着人们对SCL发展的兴趣的增加，这一全面和必要的综述可以作为SCL设备的新范式。
The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.