Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome
Anatomical evidence for in utero androgen exposure in women with polycystic ovary syndrome
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DOI：
10.1016/j.fertnstert.2005.05.061
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发表时间：
2005-12-01
影响因子：
6.7
通讯作者：
Weston, GC
中科院分区：
文献类型：
--
作者：
Cattrall, FR;Vollenhoven, BJ;Weston, GC
目的：为了确定多囊卵巢综合征（PCOS）妇女与非PCOS妇女相比是否具有男性化的手指长度模式。设计：病例对照研究。设定：大学教学医院和体外受精单位。患者：70名年龄在18岁至40岁之间的PCOS女性与70名无PCOS女性进行比较。干预措施：使用游标卡尺测量左手和右手腹侧表面上从手指基部折痕到指尖的第二至第四手指长度比。主要结果测量：第二至第四手指长度比。结果：我们发现与对照组相比，PCOS妇女右手的比例显著降低。结论：PCOS患者手指长度的几何平均值是正常对照组的98.3%（95%可信区间为99.3%~ 97.3%），这可能是PCOS患者宫内雄激素暴露的解剖学证据。
Objective: To determine whether women with polycystic ovary syndrome (PCOS) have masculinized finger length patterns compared to women without PCOS.Design: A case control study. Setting: University teaching hospital and in vitro fertilization unit.Patient(s): Seventy women aged between 18 and 40 years with PCOS were compared to 70 women without PCOS.Intervention(s): Measurement of the second to fourth finger length ratio on the ventral surface of the left and right hand from the basal crease of the digit to the tip was made using Vernier calipers.Main Outcome Measure(s): The second to fourth finger length ratio.Result(s): We found a significantly reduced ratio in the right hand of the women with PCOS compared to the controls. The geometric mean right finger length ratio in the PCOS group was 98.3% that of the controls (95% confidence interval, 99.3% - 97.3%).Gonclusion(s): Here we show a subtle difference in the finger length pattern of women with PCOS: This may constitute anatomical evidence of in utero androgen exposure in PCOS.