PEPTIDERGIC INNERVATION AND ENDOCRINE-CELLS IN THE HUMAN LIVER
PEPTIDERGIC INNERVATION AND ENDOCRINE-CELLS IN THE HUMAN LIVER
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DOI：
10.3109/00365529309104014
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发表时间：
1993-09-01
影响因子：
1.9
通讯作者：
GRIMELIUS, L
中科院分区：
文献类型：
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作者：
ELSALHY, M;STENLING, R;GRIMELIUS, L
用三种免疫组化方法对霍奇金淋巴瘤患者组织学正常的肝活检标本进行了肽能神经纤维和内分泌细胞的研究。许多免疫反应性神经纤维被视为与抗血清对周围神经标记物（神经元特异性烯醇化酶，神经丝蛋白，和S-100）。这些神经纤维位于肝动脉和门静脉分支的图尼卡中膜、胆管周围和小叶间隔的结缔组织中。在肝脏中，检测到10种肽能神经纤维：胰高血糖素、胰高血糖素样肽（GLP）、生长抑素、神经肽Y（NPY）、血管活性肠肽、神经降压素、胃泌素/胆囊收缩素C末端、P物质、5-羟色胺和甘丙肽免疫反应性神经纤维。GLP-、生长抑素-、神经肽Y-、神经降压素-、P物质-和甘丙肽免疫反应阳性神经纤维丰富，其他神经纤维稀少。神经纤维有两种不同的分布模式：它们发生在血管壁和小叶间隔的结缔组织中。胰腺多肽和NPY免疫反应细胞之间的内衬上皮细胞的胆管小叶间隔。
Histologically normal liver biopsy specimens from patients with Hodgkin's lymphoma were investigated with three immunohistochemical methods for the occurrence of peptidergic nerve fibers and endocrine cells. Numerous immunoreactive nerve fibers were seen with antisera against peripheral nerves markers (neuron-specific enolase, neurofilament protein, and S-100). These nerve fibers were localized in the tunica media of branches of both the hepatic artery and portal vein, around the bile ducts, and in the connective tissue of the interlobular septa. In the liver, 10 types of peptidergic nerve fibers were detected: glucagon-, glucagon-like peptide- (GLP), somatostatin-, neuropeptide Y- (NPY), vasoactive intestinal polypeptide-, neurotensin-, gastrin/cholecystokinin C-terminus-, substance P-, serotonin-, and galanin-immunoreactive nerve fibers. GLP-, somatostatin-, NPY-, neurotensin-, substance P-, and galanin-immunoreactive nerve fibers were abundant; the other nerve fibers were scarce. The nerve fibers showed two distinct patterns of distribution: they occurred in the blood vessel wall and in connective tissue of the interlobular septum. Pancreatic polypeptide- and NPY-immunoreactive cells were found among the lining epithelial cells of the bile ducts in the interlobular septum.