Oral health and risk of squamous cell carcinoma of the head and neck and esophagus:: Results of two multicentric case-control studies
Oral health and risk of squamous cell carcinoma of the head and neck and esophagus:: Results of two multicentric case-control studies
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DOI：
10.1093/aje/kwm193
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发表时间：
2007-11-15
影响因子：
5
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Guha, Neela;Boffetta, Paolo;Brennan, Paul
据报道，口腔健康不良是头颈癌病因学中的一个危险因素。口腔健康数据是两项多中心病例对照研究的一部分，包括中欧的924例病例和928例对照，拉丁美洲的2,286例病例和1,824例对照。从1998年至2003年，纳入了头颈部（口腔、咽、喉）和食管鳞状细胞癌的发病病例，以及年龄（五年）和性别频率匹配的对照。口腔状况不佳（中欧：比值比（OR）= 2.89，95%置信区间（CI）：1.74，4.81;拉丁美洲：OR = 1.89，95% CI：1.47，2.42），不使用牙刷（拉丁美洲：OR = 2.36，95% CI：1.28，4.36）和每日使用漱口水（拉丁美洲：OR = 3.40，95% CI：1.96，5.89）是头颈癌的危险因素，独立于吸烟和饮酒。缺失6 - 15颗牙齿是食管癌的独立危险因素（中欧：OR = 2.84，95% CI：1.26，6.41;拉丁美洲：OR = 2.18，95% CI：1.04，4.59）。这些结果表明，牙周病（如口腔状况不佳和牙齿缺失所示）和日常漱口水的使用可能是头部，颈部和食道癌症的独立原因。
Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928 controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer (central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59). These results indicate that periodontal disease (as indicated by poor condition of the mouth and missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and esophagus.