Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration
Co-inspired hydroxyapatite-based scaffolds for vascularized bone regeneration
复制标题
用于血管化骨再生的共同启发的基于羟基磷灰石的支架
DOI：
10.1016/j.actbio.2020.11.010
复制
发表时间：
2021-01-01
影响因子：
9.7
通讯作者：
Wu, Chengtie
中科院分区：
文献类型：
--
作者：
Feng, Chun;Xue, Jianmin;Wu, Chengtie
羟基磷灰石（HA）是人体骨的主要无机成分。受珍珠层和皮质骨的启发，成功制备了基于羟基磷灰石的线圈支架。支架材料呈现“砖泥”状的珍珠层多层结构和皮质骨多层同心圆结构。由于生物活性成分和分级结构，支架具有良好的抗压强度（约95 MPa）、抗弯强度（约161 MPa）和韧性（约1.1 MJ/m3）。此外，它们在大鼠和兔临界尺寸骨缺损模型中显示出改善的血管生成和骨生成。通过模拟共生物系统，本研究为优化传统组织工程生物材料的性能提供了一种可行的策略。(C)2020 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Hydroxyapatite (HA) is the main inorganic component of human bone. Inspired by nacre and cortical bone, hydroxyapatite-based coil scaffolds were successfully prepared. The scaffolds presented "brick and mortar" multi-layered structure of nacre and multi-layered concentric circular structure of cortical bone. Because of bioactive components and hierarchical structure, the scaffolds possessed good compressive strength (approximate to 95 MPa), flexural strength (approximate to 161 MPa) and toughness (approximate to 1.1 MJ/m(3)). In addition, they showed improved angiogenesis and osteogenesis in rat and rabbit critical sized bone defect models. By mimicking co-biological systems, this work provided a feasible strategy to optimize the properties of traditional tissue engineering biological materials for vascularized bone regeneration. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.