Cell Non-autonomous UPRER Signaling.
Cell Non-autonomous UPRER Signaling.
复制标题
细胞非自主 UPRER 信号传导。
DOI:
10.1007/82_2017_38
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发表时间:
2018
影响因子:
--
通讯作者:
Imanikia S
中科院分区:
文献类型:
--
作者:
Imanikia S
The UPRERis an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPRERto coordinate physiological processes between cells and tissues. Recent evidence suggests that the activation of the UPRERcan itself be communicated between cells. This cell non-autonomous route to UPRERactivation occurs in multiple species, and enables organism-wide responses to stress that involve processes as diverse as immunity, metabolism, aging and reproduction. It may also play roles in disease progression, making the pathways that mediate cell non-autonomous UPRERsignaling a potential source of novel future therapeutics.
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