Cell Non-autonomous UPRER Signaling.

Cell Non-autonomous UPRER Signaling.
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细胞非自主 UPRER 信号传导。

DOI:
10.1007/82_2017_38
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发表时间:
2018
影响因子:
--
通讯作者:
Imanikia S
Imanikia S
中科院分区:
医学3区
文献类型:
--
作者:
Imanikia S

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UPRER 是分泌途径稳态的重要调节因子,在许多生理过程中发挥作用。其广泛的靶点以及调节分泌和膜运输的能力使其完美地影响细胞间通讯,使 UPRER 能够协调细胞和组织之间的生理过程。最近的证据表明 UPRER 的激活本身可以在细胞之间传递。这种 UPRER 激活的细胞非自主途径发生在多个物种中,并使整个生物体能够对涉及免疫、新陈代谢、衰老和繁殖等多种过程的应激做出反应。它还可能在疾病进展中发挥作用,使介导细胞非自主 UPRER 信号的途径成为未来新型疗法的潜在来源。
The UPRERis an important regulator of secretory pathway homeostasis, and plays roles in many physiological processes. Its broad range of targets and ability to modulate secretion and membrane trafficking make it perfectly positioned to influence intercellular communication, enabling the UPRERto coordinate physiological processes between cells and tissues. Recent evidence suggests that the activation of the UPRERcan itself be communicated between cells. This cell non-autonomous route to UPRERactivation occurs in multiple species, and enables organism-wide responses to stress that involve processes as diverse as immunity, metabolism, aging and reproduction. It may also play roles in disease progression, making the pathways that mediate cell non-autonomous UPRERsignaling a potential source of novel future therapeutics.
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