Antiarrhythmic Properties of Long-Term Treatment with Matrine in Arrhythmic Rat Induced by Coronary Ligation
Antiarrhythmic Properties of Long-Term Treatment with Matrine in Arrhythmic Rat Induced by Coronary Ligation
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苦参碱长期治疗对冠状动脉结扎所致心律失常大鼠的抗心律失常作用
DOI：
10.1248/bpb.32.1521
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发表时间：
2009-09-01
影响因子：
2
通讯作者：
Yang, Baofeng
中科院分区：
文献类型：
--
作者：
Li, Xuelian;Chu, Weiming;Yang, Baofeng
苦参碱是中药苦参的一种单体，是治疗心律失常的潜在药物。本研究旨在阐明苦参碱对心肌梗死（MI）所致心律失常大鼠的保护作用，并进一步探讨其作用机制。通过体表心电图（ECG）观察长期口服苦参碱对冠状动脉结扎所致心律失常的影响。采用全细胞膜片钳技术记录了大鼠心肌细胞的动作电位和钾离子电流。使用扫描共聚焦显微镜测量细胞质游离Ca2+浓度（[Ca2+](i)）。心肌梗死组死亡率为19/30(63%)，苦参碱组死亡率为10130 （33%）
Matrine, a monomer of traditional Chinese medicine Sophora flavescens, is a potential drug for treatment of arrhythmia. The aim of the study is to elucidate the protective effects of matrine on arrhythmic rat induced by myocardial infarction (MI) and further explore underlying targets. Experiments were performed to investigate the effects of long-term oral administration of matrine on coronary ligation induced arrhythmia, measured in whole animals, via surface electrocardiogram (ECG). Whole-cell patch-clamp technique was used to record the action potential and potassium ionic currents in myocytes isolated from rat hearts. The cytoplasmic free Ca2+ concentration ([Ca2+](i)) was measured using the scanning confocal microscopy. Mortality rate was 19/30 (63%) in MI group and 10130 (33%) in matrine group (p