Systemic expression of a newly recognized protein, LECT2, in the human body
Systemic expression of a newly recognized protein, LECT2, in the human body
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DOI：
10.1111/j.1440-1827.1998.tb03855.x
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发表时间：
1998-11-01
影响因子：
2.2
通讯作者：
Suzuki, K
中科院分区：
文献类型：
--
作者：
Nagai, H;Hamada, T;Suzuki, K
LECT2（白细胞来源的趋化素2）是最近分离的一种由肝细胞合成的新蛋白，所有肝细胞在细胞质内均可见到LECT2的弥漫性免疫染色，本研究试图研究LECT2在除肝脏外的正常和病变人体器官和组织中的表达，使用间接免疫过氧化酶染色，发现LECT2普遍表达于血管细胞、内皮细胞和平滑肌细胞、脂肪细胞、免疫造血组织中的脑神经细胞、顶端鳞状上皮、甲状旁腺细胞、汗腺和皮脂腺上皮、Hassall小体和一些单核细胞，尽管其中一些细胞和组织在病变情况下偶尔未染色。另外，该蛋白通常呈阴性，尽管在成骨细胞、软骨细胞、心脏和骨骼肌细胞、胃肠道平滑肌细胞中偶尔呈阳性染色。以及一些组织的上皮细胞。LECT2似乎与多种细胞损伤后的细胞周期或修复过程有关。
LECT2 (leukocyte cell-derived chemotaxin 2) is a new, recently isolated protein shown to be synthesized by hepatocytes, All hepatocytes show diffuse immunostaining for LECT2 within the cytoplasm, In the present study an attempt was made to investigate the expression of LECT2 in normal and diseased human organs and tissues, other than the liver, using indirect immunoperoxidase staining, LECT2 was found to be generally expressed in vascular, endothelial and smooth muscle cells, adipocytes, cerebral nerve cells, apical squamous epithelia, parathyroid cells, sweat and sebaceous glandular epithelia, Hassall bodies and some mononuclear cells in immunohematopoietic tissue, although some of these cells and tissues were occasionally unstained in diseased conditions, Alternatively, this protein was generally negative, although it was occasionally positively stained in osteoblasts, chondrocytes, cardiac and skeletal muscle cells, smooth muscle cells of the gastrointestinal tract, and the epithelial cells of some tissues. LECT2 seems to be related to the cell cycle or repair process following damage to a variety of cells.