Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force.
Simultaneous identification of elastic properties, thickness, and diameter of arteries excited with ultrasound radiation force.
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DOI：
10.1088/0031-9155/60/13/5279
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发表时间：
2015-07-07
影响因子：
3.5
通讯作者：
Aquino W
中科院分区：
文献类型：
--
作者：
Dutta P;Urban MW;Le Maître OP;Greenleaf JF;Aquino W
动脉的弹性和几何特性一直被认为是心血管疾病的重要预测因素。这项工作提出了一种可靠的技术，用于非侵入性表征动脉血管的各向异性弹性特性以及厚度和直径。在我们的方法中，利用超声波的辐射力沿着动脉激发导波。利用群速度作为感兴趣的量来重建血管的弹性和几何特征。这项工作的主要贡献之一是基于稀疏网格搭配插值的系统方法来构建动脉的代理模型。这些替代模型又与直接搜索优化技术一起使用，以快速准确地估计弹性特性、直径和厚度。该方法的一个吸引人的特点是，一旦建立了替代模型，它就可以用于近实时识别许多不同类型的动脉。我们通过硅橡胶管和猪颈动脉的模拟实验和体外实验证明了该方法的可行性。结果表明，该方法可以可靠地识别动脉的纵向模量、厚度和直径。发现周向模量对群速度的影响很小，这使得用当前的实验设置无法识别前一个量。未来的工作将考虑周向波的测量，目的是提高周向模量的可识别性。
The elastic and geometric properties of arteries have been long recognized as important predictors of cardiovascular disease. This work presents a robust technique for the noninvasive characterization of anisotropic elastic properties as well as thickness and diameter in arterial vessels. In our approach, guided waves are excited along arteries using the radiation force of ultrasound. Group velocity is used as the quantity of interest to reconstruct elastic and geometric features of the vessels. One of the main contributions of this work is a systematic approach based on sparse-grid collocation interpolation to construct surrogate models of arteries. These surrogate models are in turn used with direct-search optimization techniques to produce fast and accurate estimates of elastic properties, diameter, and thickness. One of the attractive features of the proposed approach is that once a surrogate model is built, it can be used for near real-time identification across many different types of arteries. We demonstrate the feasibility of the method using simulated and in vitro laboratory experiments on a silicon rubber tube and a porcine carotid artery. Our results show that using our proposed method, we can reliably identify the longitudinal modulus, thickness, and diameter of arteries. The circumferential modulus was found to have little influence in the group velocity, which renders the former quantity unidentifiable using the current experimental setting. Future work will consider the measurement of circumferential waves with the objective of improving the identifiability of the circumferential modulus.