Adherence to antiretroviral medications in an inner-city population.
Adherence to antiretroviral medications in an inner-city population.
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市中心人群坚持抗逆转录病毒药物治疗。
DOI：
10.1097/00126334-199912150-00011
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Scott D. Holmberg
中科院分区：
文献类型：
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作者：
P. Weidle;Camelia E. Ganea;Kathleen L. Irwin;Joseph P. McGowan;Jerome A. Ernst;Noemi Olivo;Scott D. Holmberg
坚持抗逆转录病毒药物治疗对于艾滋病毒感染的最佳治疗至关重要。我们通过保密访谈和自我管理的匿名问卷调查，调查了市中心人群抗逆转录病毒药物治疗的不依从性。我们在访谈的前一天和前一个月估计依从性，并询问不依从的原因。在173名服用抗逆转录病毒药物的人中，所有人都参加了保密访谈，101人还完成了匿名问卷。保密访谈和匿名问卷调查的结果显示，前一天不依从任何药物的比例分别为6%和28%，前一个月分别为11%和39%。两种方法不依从的最常见原因是健忘、药物难以获得以及感知或实际毒性。在12%的匿名问卷调查中，不依从的原因之一是认为或实际缺乏药物疗效：在任何机密访谈中均未给出此原因。关于不遵守的程度及其原因的答复可能因查明方法而异。改善依从性的干预措施应侧重于使药物剂量更容易记住，确保药物的持续供应，并避免毒性。
Adherence to antiretroviral medications is essential for optimal treatment of HIV infection. We investigated nonadherence to antiretroviral medications in an inner-city population by using a confidential interview and a self-administered anonymous questionnaire. We estimated adherence on the day before and the month before the interview and asked reasons for nonadherence. Of 173 people who were taking antiretroviral medications, all participated in the confidential interview and 101 also completed the anonymous questionnaire. Results of the confidential interview and the anonymous questionnaire revealed rates of 6% and 28%, respectively, for nonadherence to any drug on the preceding day and of 11% and 39%, respectively, in the preceding month. The most common reasons for nonadherence in both methods were forgetfulness, inaccessibility of medications, and perceived or actual toxicity. On 12% of the anonymous questionnaires one reason for nonadherence was perceived or actual lack of drug efficacy: this reason was not given in any of the confidential interviews. Responses about the extent of nonadherence and the reasons for it may differ depending on the method of ascertainment. Interventions to improve adherence should focus on making medication dosages easier to remember, ensuring a continued supply of medications, and circumventing toxicities.