Acute Interaction of Baclofen in Combination With Alcohol in Heavy Social Drinkers
Acute Interaction of Baclofen in Combination With Alcohol in Heavy Social Drinkers
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DOI：
10.1111/j.1530-0277.2008.00805.x
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Bisaga, Adam
中科院分区：
文献类型：
--
作者：
Evans, Suzette M.;Bisaga, Adam
越来越多的证据表明，γ-氨基丁酸-B 受体激动剂可能有效治疗酒精滥用或酒精依赖。本研究的主要目标是确定巴氯芬与重度饮酒者饮酒联合使用的安全性。此外，还评估了巴氯芬单独使用以及与酒精联合使用对主观影响、认知表现影响以及酒精渴望的影响。 18 名未寻求治疗的重度社交饮酒者（平均每周饮酒 28 杯）参与了研究，他们不符合酒精依赖标准。所有个体均采用双盲双模拟设计进行测试，分为六个为期两天的住院阶段。巴氯芬（0、40 和 80 毫克）在饮酒（1.5 克/升体内水或约 0.75 克/公斤）或安慰剂饮料前 2.5 小时服用，每 20 分钟分 4 次服用。巴氯芬，无论单独使用还是与酒精合用，仅产生适度的心率和血压增加，并且没有不良反应的报告。巴氯芬不会增加积极的主观效应（例如，兴奋作用、药物喜好），但会增加镇静作用并损害表现。尽管巴氯芬和酒精都会损害表现，但在大多数情况下，当巴氯芬与酒精结合使用时，表现不会受到更大程度的损害。在这些非依赖饮酒者群体中，巴氯芬并没有改变对酒精的渴望或酒精引起的积极主观影响。单独使用巴氯芬在重度社交饮酒者中的滥用可能性很小，并且当与致醉剂量的酒精联合使用时，巴氯芬的耐受性相对良好且安全。
There is growing evidence that gamma-amino butyric acid-B receptor agonists may be effective in the treatment of alcohol abuse or dependence. The primary goal of this study was to determine the safety of baclofen in combination with alcohol consumption in heavy drinkers. In addition, the effects of baclofen alone, and in combination with alcohol, on subjective effects, cognitive performance effects, as well as alcohol craving, were assessed.Eighteen non-treatment-seeking heavy social drinkers (mean of 28 drinks per week), who did not meet the criteria for alcohol dependence participated. All individuals were tested using a double-blind double-dummy design with six 2-day inpatient phases. Baclofen (0, 40, and 80 mg) was administered 2.5 hours before alcohol (1.5 g/l body water or approximately 0.75 g/kg) or placebo beverages, given in 4 divided doses every 20 minutes.Baclofen, either alone or in combination with alcohol, produced only modest increases in heart rate and blood pressure and no adverse effects were reported. Baclofen did not increase positive subjective effects (e.g., Stimulant effects, Drug Liking) but did increase sedation and impair performance. Even though both baclofen and alcohol impaired performance, for the most part performance was not impaired to a greater extent when baclofen was combined with alcohol. Among this population of nondependent drinkers, baclofen did not alter alcohol craving or alcohol-induced positive subjective effects.Baclofen alone has minimal abuse liability in heavy social drinkers, and baclofen is relatively well tolerated and safe when given in combination with intoxicating doses of alcohol.