Fetal hemoglobin in polycythemia vera: cellular distribution in 50 unselected patients.
Fetal hemoglobin in polycythemia vera: cellular distribution in 50 unselected patients.
复制标题
真性红细胞增多症中的胎儿血红蛋白：50 名未经选择的患者的细胞分布。
DOI：
10.1182/blood.v53.6.1148.1148
复制
发表时间：
1979
期刊：
影响因子：
20.3
通讯作者：
G. Stamatoyannopoulos
中科院分区：
文献类型：
--
作者：
R. Hoffman;T. Papayannopoulou;S. Landaw;L. Wasserman;Q. DeMarsh;P. Chen;G. Stamatoyannopoulos
本文对50例未经选择的真性红细胞增多症患者的胎儿血红蛋白进行了研究，用化学方法测定了Hb-F，并用荧光抗体测定了F-细胞水平。虽然大多数患者的Hb-F产量与正常对照组无差异，但在20%的患者中，F-细胞值高于正常范围。在研究时，F细胞值与病程、治疗方式、骨髓纤维化的存在或血液学参数之间没有相关性。在50名患者中，有5名患者的红细胞中有30%-45%含有Hb-F；这种显著的F细胞升高可能反映了某些红系前体细胞在某些疾病中的扭曲分化。
Fetal hemoglobin was studied in 50 unselected patients with polycythemia vera with chemical determinations of Hb F and measurements of F-cell levels using fluorescent anti-Hb F antibodies. Although in the majority of the patients Hb F production did not differ from that in normal controls, in 20% of the patients F-cell values were above the normal range. There was no correlation between F-cell values and duration of disease, treatment modality, presence of myelofibrosis, or hematologic parameters at the time of study. In 5 of 50 patients 30%--45% of the erythrocytes contained Hb F; such striking elevations of F cells may reflect a distorted differentiation of erythroid precursor cells in certain patients with this disorder.