The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study
The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study
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DOI：
10.1111/j.1742-1241.2008.01733.x
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发表时间：
2008-05-01
影响因子：
2.6
通讯作者：
Hong, T.
中科院分区：
文献类型：
--
作者：
Gao, H.;Xiao, W.;Hong, T.
目的：研究二甲双胍缓释片（MXR）与二甲双胍速释片（MIR）对2型糖尿病患者餐后血糖波动、慢性高血糖、血脂、胰岛素抵抗和胰岛功能的影响。方法：采用随机、开放、阳性对照的多中心研究方法，对150例中国2型糖尿病患者进行研究。在2周的MIR导入期后，150例受试者被随机分配至MXR组和MIR组。MXR组给予MXR 1500 mg，餐后1次/d，MIR组给予MIR 500 mg，餐后1次/d，共12周。在基线和本研究结束时进行标准膳食试验。测定血糖、血清胰岛素、糖化血红蛋白（HbA 1c）和血脂。采用稳态模型评估（HOMA）评价胰岛素抵抗指数（HOMA-IR）和胰岛β细胞功能指数（HOMA-B）。结果：无论是MIR或MXR温和，但显着降低HbA 1c水平和体重指数（BMI）治疗12周后。但两组间无显著性差异。MXR组标准餐后120 min的餐后血糖高于MIR组（11.02 +/- 3.08 mmol/l vs. 9.74 +/- 2.61 mmol/l，p < 0.05）。治疗12周后，胰岛素释放反应曲线下面积、HOMA-B、HOMA-IR和血脂谱在组内或组间均无差异。结论：在东方人群中，每日一次MXR对慢性高血压、BMI、血脂、胰岛素抵抗和胰岛功能的影响与每日三次MIR相当。
Aim: To investigate the effects of extended-release metformin (MXR) compared with immediate-release metformin (MIR) on post-prandial glycaemic excursion, chronic glycaemia, lipid profiles, insulin resistance and islet function in type 2 diabetes. Methods: A randomised, open-labelled, positive-controlled multicentre study was conducted on 150 Chinese patients with type 2 diabetes. After 2 weeks of run-in period with MIR, 150 subjects were randomised into MXR group and MIR group. The patients in MXR group were assigned to take MXR 1500 mg once daily after dinner, while the patients in MIR group were assigned to continue MIR 500 mg thrice daily after meals for 12 weeks. Standard meal tests were carried out at baseline and at the end of this study. Plasma glucose, serum insulin, HbA1c and lipid profiles were measured. Homeostasis model assessment (HOMA) was used to evaluate insulin resistance index (HOMA-IR) and islet beta-cell function index (HOMA-B). Results: Either MIR or MXR modestly, but significantly decreased HbA1c levels and body mass index (BMI) after 12 weeks of treatment. However, there were no significant differences between two groups. The post-prandial glycaemia at 120 min after a standard meal in MXR group was higher than in MIR group (11.02 +/- 3.08 mmol/l vs. 9.74 +/- 2.61 mmol/l, p < 0.05). Moreover, no differences in the areas under curve of insulin release response, HOMA-B, HOMA-IR and lipid profiles were found within or between groups after 12 weeks of treatment. Conclusion: The effects of once daily MXR on chronic glycaemia, BMI, lipid profiles, insulin resistance and islet function are comparable with that of thrice daily MIR in oriental population.