EFFECTS OF ETHANOL ON CELLULAR MEMBRANE POTENTIALS AND CONTRACTILITY OF ISOLATED RAT ATRIUM
EFFECTS OF ETHANOL ON CELLULAR MEMBRANE POTENTIALS AND CONTRACTILITY OF ISOLATED RAT ATRIUM
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DOI：
10.1152/ajplegacy.1962.203.1.194
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发表时间：
1962-01-01
影响因子：
--
通讯作者：
WEBB, JL
中科院分区：
文献类型：
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作者：
GIMENO, AL;GIMENO, MF;WEBB, JL
同时观察乙醇对心房肌细胞收缩力和电特性的影响。使用微电极测定单细胞膜电位;从灵敏的应变计记录机械活动。浓度在24和192 m之间的乙醇[图片]（110-880 mg/100 ml）抑制大鼠心房的收缩性，收缩抑制与浓度之间的关系基本上是线性的。这些影响在所有情况下都是可逆的。动作电位的明确缩短与收缩力的降低同时发生，是电特性中最典型的变化。这是由于复极速率更快所致。动作电位的幅度略有下降，而静息电位和去极化率不受乙醇的影响。收缩性的抑制可部分归因于动作电位的缩短，但除此之外，似乎对收缩机制有一些更直接的作用。动作电位持续时间的减少可能使心房易发生节律障碍，如异位搏动和纤维性颤动。
The simultaneous effects of ethanol on the contractility and electrical characteristics of atrial cells were examined. Single cell membrane potentials were determined using microelectrodes; the mechanical activity was recorded from a sensitive strain gauge. Ethanol at concentrations between 24 and 192 m[image] (110-880 mg/100 ml) depresses the contractility of the rat atria, the relationship between contractile depression and concentration being essentially linear. The effects are reversible in all cases. A definite shortening of the action potential, simultaneous with the reduction in contractility, is the most characteristic change in the electrical properties. This results from a more rapid rate of repolarization. The magnitude of the action potential is decreased slightly, whereas the resting potential and the depolarization rate are unaffected by ethanol. The depression of the contractility can be partially attributed to the shortening of the action potential but, in addition, there would appear to be some more direct action on the contractile mechanism. The decrease in the duration of the action potential may predispose the atria to dysrhythmias, such as ectopic beats and fibrillation.