Developmental regulation of Tbx5 in zebrafish embryogenesis
Developmental regulation of Tbx5 in zebrafish embryogenesis
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DOI：
10.1016/s0925-4773(99)00246-4
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发表时间：
2000-02-01
影响因子：
2.6
通讯作者：
Ingham, PW
中科院分区：
文献类型：
--
作者：
Begemann, G;Ingham, PW
T-box（rbs）基因组成了一个转录调控因子大家族，参与发育模式化过程。在四足动物中，tbx 5与前肢类型的确定有关。在这里，我们报告了斑马鱼tbx5.1基因的克隆和表达在斑马鱼胚胎发育和早期幼虫发育的野生型和突变胚胎，影响胸鳍图案。tbx5.1在心脏、胸鳍和眼睛的发育过程中表达。值得注意的是，它在侧板中胚层中的表达定义了心脏和胸鳍前体细胞的单个连续区域，并构成了斑马鱼胸鳍发育的最早特异性标记。(C)2000爱思唯尔科学爱尔兰有限公司保留所有权利。
T-box (rbs) genes constitute a large family of transcriptional regulators involved in developmental patterning processes. In tetrapods, tbx5 has been implicated in specifying forelimb type identity. Here, we report the cloning of the zebrafish tbx5.1 gene and characterise its expression during zebrafish embryogenesis and early larval development of wild type and mutant embryos that affect pectoral fin patterning. tbx5.1 is expressed during development of the heart, the pectoral fins and the eye. Notably, its expression in the lateral plate mesoderm defines a single and continuous region of heart and pectoral fin precursor cells, and constitutes the earliest specific marker for pectoral fin development in the zebrafish. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.