Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
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DOI：
10.1086/507566
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发表时间：
2006-09
影响因子：
9.8
通讯作者：
M. Tošić;J. Ott;S. Barral;P. Bovet;P. Deppen;F. Gheorghita;Marie-Louise Matthey;J. Parnas;M. Pr
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文献类型：
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作者：
M. Tošić;J. Ott;S. Barral;P. Bovet;P. Deppen;F. Gheorghita;Marie-Louise Matthey;J. Parnas;M. Pr
氧化应激可能与精神分裂症（一种主要的精神疾病）的病理生理学有关。谷胱甘肽（GSH）是一种氧化还原调节剂，在患者的脑脊液和前额皮质中减少。在两项病例对照研究和一项家庭研究中，关键的 GSH 合成酶、谷氨酸半胱氨酸连接酶修饰剂 (GCLM) 亚基的基因与精神分裂症密切相关。患者成纤维细胞中的 GCLM 基因表达降低。因此，GSH代谢功能障碍被认为是精神分裂症的易感因素之一。
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.