Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin
Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin
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DOI：
10.1016/j.nut.2005.09.003
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发表时间：
2006-02-01
期刊：
影响因子：
4.4
通讯作者：
Costa, NMB
中科院分区：
文献类型：
--
作者：
Cintra, DEC;Costa, AGV;Costa, NMB
目的：膳食饱和脂肪酸与冠心病相关。相反，饮食中的单不饱和多不饱和脂肪酸(MUFAs)和多不饱和脂肪酸(PUFAs)似乎具有保护作用。以高脂饲料喂养的大鼠为研究对象，分别添加不同来源的PUFA(亚麻籽和鲑鱼)、MUFA(花生)和饱和脂肪酸(鸡皮)。方法：成年雄性Wistar大鼠分为6组(n=10)：正常对照组；高脂饲料组，添加1%胆固醇、10%大豆油和5%猪油；4组饲料中添加10%脂肪，分别为鲑鱼、亚麻籽、花生和鸡皮。28d后处死动物。结果：饲喂普通饲料的大鼠血清总胆固醇(93.57+/-14.95 mg/dL)高于饲喂HF饲料的大鼠(67.57+/-12.54 mg/dL)(P<；0.05)。喂食亚麻籽饲料的老鼠的总胆固醇水平低于喂食其他脂肪的老鼠(P<；0.05)。饲喂花生组和鸡皮饲料组之间的胆固醇水平没有差异(P>；0.05)。与其他处理组的动物相比，喂食花生饮食的动物体重增加明显减少。饲喂HF饲料的大鼠肝脏中有大量的脂肪和胆固醇沉积。脂肪组织中的脂肪沉积遵循相同的膳食脂肪酸分布，即亚麻籽组高水平的omega-3 PUFA，花生组和鸡皮组高水平的MUFA，以及鲑鱼组高水平的omega-6 PUFA。结论：这些数据表明亚麻籽组有望用于高脂血症的饮食调控。(C)2006 Elsevier Inc.保留所有权利。
Objective: Dietary saturated fatty acids are associated with coronary disease. Conversety, dietary monounsaturated polyunsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) seem to exert a protective effect. This study evaluated the lipid profile of rats fed high-fat (HF) diets, with fat added as different sources of PUFA (flaxseed and trout), MUFA (peanut), and saturated fatty acid (chicken skin).Methods: Adult male Wistar rats were placed into six dietary groups (n = 10): control (normal); high fat, with 1% cholesterol, 10% soy oil, and 5% lard; and four groups fed similar HF diets, with 10% lipid as trout, flaxseed, peanut, or chicken skin. After 28 d the animals were killed. Blood, livers, and adipose tissue samples were collected.Results: A higher level (P < 0.05) of total serum cholesterol was observed in rats fed the normal diet (93.57 +/- 14.95 mg/dL) compared with those fed the HF diet (67.57 +/- 12.54 ing/dL). Total cholesterol levels in rats fed the flaxseed diet were lower (P < 0.05) than in rats fed the other fats. No difference was observed in cholesterol levels between groups fed the peanut and chicken skin diets (P > 0.05). Animals fed the peanut diet showed decreased body weight gain than did animals in the other treatment groups. There were large lipid and cholesterol depositions in livers of rats fed the HF diet. Lipid deposition in adipose tissue followed the same dietary fatty acid profile, i.e., high levels of omega-3 PUFA in the flaxseed group, high levels of MUFA in the peanut and chicken skin groups and high levels of omega-6 PUFA in the trout group.Conclusions: These data indicate that flaxseed is promising for dietary manipulation of hyperlipidemia. (c) 2006 Elsevier Inc. All rights reserved.