Coronary CT angiography derived fractional flow reserve: Methodology and evaluation of a point of care algorithm
Coronary CT angiography derived fractional flow reserve: Methodology and evaluation of a point of care algorithm
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DOI：
10.1016/j.jcct.2015.12.006
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发表时间：
2016-03-01
影响因子：
5.4
通讯作者：
Nieman, Koen
中科院分区：
文献类型：
--
作者：
Coenen, Adriaan;Lubbers, Marisa M.;Nieman, Koen
背景资料：最近几篇出版物描述了冠状动脉CT血管造影（冠状动脉CTA）衍生血流储备分数（CTA-FFR）的诊断价值。对于最近引入的现场CTA-FFR应用程序，尚未描述可能影响性能的详细方法和因素。Objective：为现场CTA-FFR应用程序提供方法学背景，并评估患者和采集特征的影响。Methods：现场CTA-FFR应用程序利用了在狭窄区域内应用压降模型的降阶混合模型。在116例患者和203支血管中，使用有创FFR测量值作为参考，研究了CTA-FFR的诊断性能。结果：根据有创血流储备分数（阈值），90支（44%）血管存在血流动力学相关狭窄
Background: Recently several publications described the diagnostic value of coronary CT angiography (coronary CTA) derived fractional flow reserve (CTA-FFR). For a recently introduced on-site CTA-FFR application, detailed methodology and factors potentially affecting performance have not yet been described.Objective: To provide a methodological background for an on-site CTA-FFR application and evaluate the effect of patient and acquisition characteristics.Methods: The on-site CTA-FFR application utilized a reduced-order hybrid model applying pressure drop models within stenotic regions. In 116 patients and 203 vessels the diagnostic performance of CTA-FFR was investigated using invasive FFR measurements as a reference. The effect of several potentially relevant factors on CTA-FFR was investigated.Results: 90 vessels (44%) had a hemodynamically relevant stenosis according to invasive FFR (threshold