Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
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DOI：
10.1016/j.febslet.2012.04.021
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发表时间：
2012-05-21
期刊：
影响因子：
3.5
通讯作者：
Tsujimoto, Gozoh
中科院分区：
文献类型：
--
作者：
Inoue, Daisuke;Kimura, Ikuo;Tsujimoto, Gozoh
突触蛋白是包裹突触小泡的神经元磷蛋白，被认为在调节神经递质释放中发挥作用。使用原代培养的小鼠颈交感神经节神经元检查了短链游离脂肪酸 (SCFA) 刺激 NE 释放的信号机制。药理学和敲除实验表明，SCFA 丙酸盐激活交感神经元涉及 SCFA 受体 GPR41 连接到 G beta gamma-PLC beta 3-ERK1/2-synapsin 2 信号传导。此外，突触蛋白 2b 直接与激活的 ERK1/2 相互作用，并且当 SCFA 激活交感神经元时可以在丝氨酸上磷酸化。 (c) 2012 年欧洲生化学会联合会。由 Elsevier B.V. 出版。保留所有权利。
Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G beta gamma-PLC beta 3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.