Expired air carbon monoxide and serum thiocyanate as objective measures of cigarette exposure.
Expired air carbon monoxide and serum thiocyanate as objective measures of cigarette exposure.
复制标题
呼出空气一氧化碳和血清硫氰酸盐作为香烟暴露的客观指标。
DOI：
10.2105/ajph.67.6.545
复制
发表时间：
1977
影响因子：
12.7
通讯作者：
S. Hulley
中科院分区：
文献类型：
--
作者：
T. Vogt;S. Selvin;G. Widdowson;S. Hulley
使用过期空气一氧化碳（CO）和血清硫氰酸盐（SCN）来评估139名中年男性的香烟暴露情况。报告吸烟的受试者通常CO水平超过8ppm， SCN水平超过100umol/L；不吸烟者的水平较低。在这两项测试中，每天吸烟超过一包的男性的平均浓度是不吸烟者的三倍。这两项测试之间的相关性很高（吸烟者的r= 0.571），这种相关性在很大程度上独立于两项测试与报告吸烟频率之间的较小相关性（CO的r= 0.476； SCN的r= 0.479）。当CO和SCN分析一起使用以利用其单独的方差来源时，区分报告“典型”吸烟习惯的个体和非吸烟者的能力最好；当两种测试相互一致时，这一比例为99%（91%的病例）。CO和SCN测量允许将16名报告轻度吸烟习惯的人分为高推定烟草暴露组和低推定烟草暴露组。这两种检测方法价格低廉，适用于流行病学和卫生保健项目。
Expired air carbon monoxide (CO) and serum thiocyanate (SCN) were used to asses exposure to cigarettes in 139 middle-aged men. Subjects who reported smoking cigarettes generally had CO levels exceeding 8ppm and SCN levels exceeding 100umol/L; non-smokers had lower levels. For both tests the mean concentration among men smoking more than one pack daily was three times that of non-smokers. The is a high correlation between the two tests (r=.571 for smokers), an association that was largely independent of the smaller correlations between either test and reported smoking frequency (r=.476 for CO; r=.479 for SCN). The ability to distinguish between individuals who reported "typical" smoking habits and non-smokers was best when the CO and SCN analyses were used together to take advantage of their separate sources of variance; it was 99 per cent when the two tests were mutually concordant (91 per cent of cases). The CO and SCN measurements allowed 16 individuals who reported light smoking habits to be categorized into high and low presumptive tobacco exposure groups. The two tests are inexpensive and suitable for use in epidemiologic and health care delivery programs.