Zinc-α2-glycoprotein expression as a marker of differentiation in human oral tumors
Zinc-α2-glycoprotein expression as a marker of differentiation in human oral tumors
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DOI：
10.1016/s0304-3835(98)00347-4
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发表时间：
1999-03-22
期刊：
影响因子：
9.7
通讯作者：
Arany, I
中科院分区：
文献类型：
--
作者：
Brysk, MM;Lei, G;Arany, I
锌-α(2)-糖蛋白 (Zn α(2)gp) 是一种可溶性主要组织相容性复合体同源物，广泛存在于体液和腺上皮中；作者最近证明了它存在于复层上皮中。 Zn α(2)gp 与乳腺癌和其他癌症的肿瘤分化有关。我们在此比较了其在组织病理学分级的口腔鳞状细胞癌及其病灶周围正常细胞中的基因表达。对照中的 Zn α(2)gp 水平高于肿瘤中的水平，并且分化良好的肿瘤中的 Zn α(2)gp 水平高于分化不良的肿瘤中的水平。口腔上皮成熟的标志物（角蛋白 K13 和外皮蛋白）与肿瘤组织学的关系不太简单。 (C) 1999 年由爱思唯尔科学有限公司出版。保留所有权利。
Zinc-alpha(2)-glycoprotein (Zn alpha(2)gp) is a soluble major histocompatibility complex homolog widespread in body fluids and in glandular epithelia; the authors recently demonstrated its presence in stratified epithelia. Zn alpha(2)gp has been associated with tumor differentiation in breast cancers and other carcinomas. We compare here its gene expression in histopathologically graded oral squamous cell carcinomas and in their perilesional normals. Zn alpha(2)gp levels are higher in the controls than in the tumors, and higher in well-differentiated tumors than in poorly differentiated ones. Markers of oral epithelial maturation (keratin K13 and involucrin) are less simply related to tumor histology. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.