Wound repair and regeneration: mechanisms, signaling, and translation.
Wound repair and regeneration: mechanisms, signaling, and translation.
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DOI：
10.1126/scitranslmed.3009337
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发表时间：
2014-12-03
影响因子：
17.1
通讯作者：
Tomic-Canic M
中科院分区：
文献类型：
--
作者：
Eming SA;Martin P;Tomic-Canic M
支持组织修复和愈合失败的细胞和分子机制仍然知之甚少，目前的治疗方法也有限。创伤、手术、急性疾病或慢性疾病后创面愈合不良每年影响全球数百万人，是健康组织修复反应调控不当的结果，包括炎症、血管生成、基质沉积和细胞募集。这些细胞过程中的一个或几个过程的失败通常与潜在的临床状况有关，如血管疾病、糖尿病或衰老，这些都经常与愈合病理有关。寻找可能改善人体自然修复机制的临床策略，将需要基于对修复和再生的基本生物学的透彻理解。在这篇综述中，我们强调了组织再生和修复方面的新兴概念，并就如何将当前的知识转化为可行的临床方法来治疗创面愈合病理患者提供了一些观点。
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body’s natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.