eIF4E, the mRNA cap-binding protein: from basic discovery to translational research
eIF4E, the mRNA cap-binding protein: from basic discovery to translational research
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DOI：
10.1139/o08-034
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发表时间：
2008-04-01
影响因子：
2.9
通讯作者：
Sonenberg, Nahum
中科院分区：
文献类型：
--
作者：
Sonenberg, Nahum
翻译调控是真核细胞调控基因表达的重要手段。翻译是遗传信息流动的最后一步，在这一水平上的调控允许对生理条件下的变化做出即时和快速的反应。由于mRNA的生物发生过程，包括转录、剪接和向细胞质的输出，都是耗时的，因此通过控制翻译来使用已有的mRNA在许多情况下是有利的。翻译控制的主要目标是起始因子eIF4E，它识别所有核转录的真核mrna的5'端存在的m7GpppN帽结构。在这篇文章中，我描述了eIF4E的发现，它在翻译起始中的作用机制，以及它在控制癌症和先天免疫中的作用。
Translational control is an important strategy by which eukaryotic cells regulate gene expression. Translation is the last step in the flow of genetic information, and regulation at this level allows an immediate and rapid response to changes under physiological conditions. Because the processes of mRNA biogenesis, including transcription, splicing, and export to the cytoplasm, are time consuming, the use of pre-existing mRNAs via the control of translation is advantageous in many circumstances. A prime target of translational control is the initiation factor eIF4E, which recognizes the m7GpppN cap structure present at the 5' end of all nuclear transcribed eukaryotic mRNAs. In this article I describe the discovery of eIF4E, its mechanism of action in translation initiation, and its role in the control of cancer and innate immunity.