Management of sleep disorders in Parkinson's disease and multiple system atrophy.
Management of sleep disorders in Parkinson's disease and multiple system atrophy.
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DOI：
10.1002/mds.26918
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Videnovic A
中科院分区：
文献类型：
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作者：
Videnovic A
帕金森病（PD）和多系统萎缩（MSA）是与α突触核蛋白相关的神经变性相关的疾病。非运动症状是这些疾病的共同特征，睡眠-觉醒周期紊乱是最常见的非运动症状之一。直到最近，睡眠障碍才受到医学和研究界的关注。在过去的几十年里，在了解α突触核蛋白病的睡眠和觉醒中断的病理生理学方面取得了重大进展。尽管取得了这些进展，但治疗选择有限，并且经常与有问题的副作用有关。非常需要以开发新的治疗方法为中心的进一步研究。本文就PD和MSA患者睡眠和警觉性障碍的治疗现状进行综述。
Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Non-motor symptoms are common hallmarks of these disorders, and disturbances of sleep-wake cycle are among the most common non-motor symptoms. It is only recently that sleep disturbances have received the attention of the medical and research community. Significant progress has been made in understanding the pathophysiology of sleep and wake disruption in alpha synucleinopathies over the past few decades. Despite these advancements, treatment options are limited and frequently associated with problematic side effects. Further studies that will center on development of novel treatment approaches are very much needed. In this article we review discuss current state of managements of disturbed sleep and alertness in PD and MSA.