Efficient Algorithms Unlock Understanding of Clonal Evolution in Cancer.
Efficient Algorithms Unlock Understanding of Clonal Evolution in Cancer.
复制标题
高效的算法解锁了对癌症克隆进化的理解。
DOI：
10.1158/2643-3230.bcd-22-0036
复制
发表时间：
2022
影响因子：
11.2
通讯作者：
Miller,ChristopherA
中科院分区：
文献类型：
--
作者：
Miller,ChristopherA
在这一期的《血癌发现》杂志上，Wintersinger和他的同事提出了一种新的算法，可以快速准确地从许多时间点和/或许多地点的异质性肿瘤中推断克隆系统发育。当与肿瘤序列测序相结合时，这一进展有望增加我们对塑造肿瘤进化和对治疗反应的克隆动力学的理解。看到相关文章Wintersinger et al ., p。208(9)。
In this issue ofBlood Cancer Discovery, Wintersinger and colleagues present a new algorithm for quickly and accurately inferring clonal phylogenies from heterogeneous tumors sampled at many timepoints and/or many sites. When coupled with serial sequencing of tumors, this advance promises to increase our understanding of the clonal dynamics that shape tumor evolution and response to therapy.See related article by Wintersinger et al., p. 208 (9).