ANTIBIOTICA AUS ACTINOMYCCTEN .6. PIKROMYCIN, EIN BITTER SCHMECKENDES ANTIBIOTICUM AUS ACTINOMYCETEN
ANTIBIOTICA AUS ACTINOMYCCTEN .6. PIKROMYCIN, EIN BITTER SCHMECKENDES ANTIBIOTICUM AUS ACTINOMYCETEN
复制标题
DOI：
10.1002/cber.19510840306
复制
发表时间：
1951-01-01
期刊：
影响因子：
--
通讯作者：
HENKEL, W
中科院分区：
文献类型：
--
作者：
BROCKMANN, H;HENKEL, W
从一种链霉菌（Streptomyces）（326）的培养液中分离到一种新的抗生素，它是一种高粘度的棕色蒸发残渣，对金黄色葡萄球菌的活性可达1：200，000。色谱吸附最初失败，但在90%甲醇和石油醚之间分配后非常成功。得到的最佳级分对S.金黄色葡萄球菌高达1：1000000。用荧光AlOH 2进行的色谱显示出恒定的、明确的区域，其对应于抗生素。通过将碱性物质转移到酸性溶剂中得到进一步纯化。乙醚馏分的缓慢蒸发导致该物质的第一个晶体。温和碱性水解的无氮降解产物具有C20H30O5的经验式。
A new antibiotic from a species of Streptomyces (326) was isolated from the culture medium in form of a highly viscous, brown evaporation residue, which was active up to 1:200,000 aganist Staphylococcus aureus. The chromatographical adsorption failed initially, but was very successful after distribution between 90% methanol and petroleum ether. The best fraction obtained was antibiotically active against S. aureus up to 1:1,000,000. Chromatography with fluorescent AlOH2 showed a constant, well defined zone, which corresponds with the antibiotic. Further purification was obtained by transmission of the basic substance into acid solvents. Slow evaporation of the ether fraction led to the first crystals of the substance. The N-free degradation product of mild alkaline hydrolysis has an empirical formula of C20H30O5.