OCCUPATIONAL AND OTHER NONDIETARY RISK-FACTORS FOR NASOPHARYNGEAL CARCINOMA IN GUANGZHOU, CHINA
OCCUPATIONAL AND OTHER NONDIETARY RISK-FACTORS FOR NASOPHARYNGEAL CARCINOMA IN GUANGZHOU, CHINA
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DOI：
10.1002/ijc.2910450609
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发表时间：
1990-06-15
影响因子：
6.4
通讯作者：
HENDERSON, BE
中科院分区：
文献类型：
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作者：
YU, MC;GARABRANT, DH;HENDERSON, BE
我们对306例经组织学证实的鼻咽癌（NPC）病例进行了访谈，这些病例发生在中国广州市，年龄在50岁以下，以及相同数量的年龄、性别和社区匹配的对照组。我们还采访了110名45岁以下患者的母亲和139名对照患者的母亲，这些母亲与45岁以下的患者相匹配，以获得有关研究对象童年暴露的信息。职业暴露于燃烧产物（RR = 2.4,p= 0.001）和棉尘（RR = 0.3, p= 0.01）与鼻咽癌风险独立相关。烟草制品的使用与鼻咽癌有中度关联；终身暴露于30包年以上相当于增加了2倍的风险。慢性耳鼻炎病史（鼻炎、鼻窦炎、鼻息肉、中耳炎）是鼻咽癌的另一个危险因素（RR = 2.2,p< 0.0005），与3例对照相比，18例与鼻咽癌有一级亲属关系（RR = 6.0,p= 0.001）。
We conducted interviews on 306 histologically confirmed incident cases of nasopharyngeal carcinoma (NPC) occurring in residents of Guangzhou City, China, who were under the age of 50, and an equal number of age‐, sex‐, and neighborhood‐matched controls. We also interviewed 110 mothers of patients under 45 and 139 mothers of controls who were matched to patients under age 45, to obtain information on childhood exposures of study subjects. Occupational exposure to products of combustion (RR = 2.4,p= 0.001) and cotton dust (RR = 0.3, P = 0.01) was independently related to risk of NPC. Use of tobacco products showed a moderate association with NPC; a lifetime exposure of 30+ pack‐year equivalents conferred a 2‐fold increased risk. A history of chronic ear or nose condition (rhinitis, sinusitis, nasal polyp, otitis media) was another risk factor for NPC (RR = 2.2,p< 0.0005), and 18 cases compared to 3 controls had a first‐degree relative with NPC (RR = 6.0,p= 0.001).