Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention
Differential cortical acetylcholine release in rats performing a sustained attention task versus behavioral control tasks that do not explicitly tax attention
复制标题
DOI：
10.1016/s0306-4522(02)00292-0
复制
发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Bruno, JP
中科院分区：
文献类型：
--
作者：
Arnold, HM;Burk, JA;Bruno, JP
本研究使用微透析技术来比较执行需要持续注意力的任务的大鼠与执行两个对照程序的大鼠额顶皮层的乙酰胆碱释放。这两个控制程序是一个固定间隔的 9 秒强化计划，主要评估操作响应和可比奖励率的影响，以及一个旨在测试杠杆延伸对提示响应的影响的操作程序。这两个控制程序涉及与持续注意力任务相当的感觉运动和动机变量，但没有明确地对注意力过程进行征税。持续注意力任务的表现与皮质乙酰胆碱流出量的显着增加相关，最高达到接近 140%。两种控制程序的表现与皮质乙酰胆碱释放的显着较小（类似于 50%）的增加相关。注意力和控制性能之间的这种强烈分离与皮质乙酰胆碱释放的增加有关，部分原因是消除了动物进入操作室的馅饼任务转移以及先前研究中观察到的乙酰胆碱释放的相关增加。目前的结果支持这样的假设，即需要注意力表现，而不是按下杠杆的频率、奖励传递和其他与任务相关的变量，选择性地激活基底前脑皮质胆碱能系统。 (C) 2002 国际广播组织。由爱思唯尔科学有限公司出版。保留所有权利。
The present study used microdialysis techniques to compare acetylcholine release in the frontoparietal cortex of rats performing in a task requiring sustained attention with that of rats performing in two control procedures. The two control procedures Were a fixed-interval 9-s schedule of reinforcement assessing primarily the effects of operant responding and comparable reward rates, and an operant procedure designed to test the effects of lever extension to prompt responding. These two control procedures involved comparable sensory-motor and motivational variables to those of the sustained attention task, but did not explicitly tax attentional processes. Performance of the sustained attention task was associated with a significant increase in cortical acetylcholine efflux, reaching a maximum of nearly 140%. Performance of the two control procedures was associated with significantly smaller ( similar to 50%) increases in cortical acetylcholine release. This robust dissociation between attentional and control performance-associated increases in cortical acetylcholine release resulted, in part, from the elimination of the pie-task transfer of the animals into the operant chambers and the associated increases in acetylcholine release observed in previous studies. The present results support the hypothesis that demands on attentional performance, as opposed to the frequency of lever pressing, reward delivery and other task-related variables, selectively activate the basal forebrain corticopetal cholinergic system. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.