Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus
Risk Factors in Cardiovascular Disease in Systemic Lupus Erythematosus
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DOI：
10.2174/1573403x11309010003
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发表时间：
2013-01-01
影响因子：
1.9
通讯作者：
Appenzeller, Simone
中科院分区：
文献类型：
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作者：
Angelica Sinicato, Nailu;da Silva Cardoso, Priscila Aparecida;Appenzeller, Simone
系统性红斑狼疮（SLE）是一种慢性、多系统的自身免疫性疾病，主要累及女性。SLE患者受疾病影响超过5年的最常见死亡原因是心血管疾病（CVD）。流行病学观察表明，与经典的传统风险因素一起，其他机制（非传统/疾病特异性因素）促进炎症性疾病（如SLE）中动脉粥样硬化的加速。传统的CVD危险因素包括年龄、高血压、糖尿病、血脂异常、既往血管事件（定义为既往脑血管意外或缺血性心脏病史）、绝经和吸烟。SLE的非传统因素包括狼疮性肾炎（LN）等疾病特异性肾脏疾病表现、促炎细胞因子、某些炎症介质、抗磷脂抗体、抗oxLDL抗体、皮质类固醇使用和累积剂量的皮质类固醇。我们将回顾与SLE患者CVD相关的传统和非传统危险因素。
Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in SLE patients affected by disease for more than 5 years is cardiovascular disease (CVD). Epidemiological observations suggest that, together with classical conventional risk factors, other mechanisms (non-conventional/disease-specific factors) promote accelerated atherosclerosis in inflammatory diseases like SLE. Traditional CVD risk factors included age, hypertension, diabetes mellitus, dyslipidemia, previous vascular event defined as previous history of cerebrovascular accidents or ischemic heart disease, menopause and smoking. The non-traditional factors presents in SLE are disease-specific like renal disease manifestation as Lupus nephritis (LN), presence of pro-inflammatory cytokines, some of inflammatory mediators, antiphospholipid antibodies, anti-oxLDL antibodies, corticosteroid uses and cumulative dose of glucocorticoids. We will review traditional and non-traditional risk factors associated with CVD in SLE patients.