Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen
Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen
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DOI：
10.1097/wno.0b013e318175c6f5
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发表时间：
2008-06-01
影响因子：
2.9
通讯作者：
Keltner, John L.
中科院分区：
文献类型：
--
作者：
Choi, Stacey S.;Zawadzki, Robert J.;Keltner, John L.
背景：新技术可以更精确地定义所有视网膜层的结构改变，尽管以前从未在视盘玻璃疣病例中使用过。方法：通过泛光照明眼底相机，使用层云和傅里叶域 (FD) 光学相干断层扫描 (OCT) 和自适应光学 (AO)，我们研究了一名患有长期视盘玻璃疣和缺血性视神经病变导致的高海拔急性视力丧失的患者的视网膜。结果： Stratus OCT 和 FD-OCT 证实视网膜神经纤维层 (RNFL) 严重变薄。 FD-OCT 显示了迄今为止未在视盘玻璃疣患者中描述的感光层紊乱。 AO 证实了光感受器层的 FD-OCT 结果，并且还显示视网膜位置的锥体密度降低与视觉敏感性降低相关。结论：根据这项研究，在视神经玻璃疣并发缺血性视神经病变的情况下，不仅 RNFL 发生变化，而且光感受器层也发生变化。这是首次报道 FD-OCT 和 AO 在这种情况下的应用。这种新的成像技术将来可能可以更精确地监测疾病进展。
Background: New technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic disc drusen.Methods: Using Stratus and Fourier domain (FD) optical coherence tomography (OCT) and adaptive optics (AO) through a flood-illuminated fundus camera, we studied the retinas of a patient with long-standing optic disc drusen and acute visual loss at high altitude attributed to ischemic optic neuropathy.Results: Stratus OCT and FD-OCT confirmed severe thinning of the retinal nerve fiber layer (RNFL). FD-OCT revealed disturbances in the photoreceptor layer heretofore not described in optic disc drusen patients. AO confirmed the FD-OCT findings in the photoreceptor layer and also showed reduced cone density at retinal locations associated with reduced visual sensitivity.Conclusions: Based on this study, changes occur not only in the RNFL but also in the photoreceptor layer in optic nerve drusen complicated by ischemic optic neuropathy. This is the first reported application of FD-OCT and the AO to this condition. Such new imaging technology may in the future allow monitoring of disease progression more precisely and accurately.