Nocturnal ACTH, cortisol, growth hormone, and prolactin secretion in prepubertal depression
Nocturnal ACTH, cortisol, growth hormone, and prolactin secretion in prepubertal depression
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DOI：
10.1097/00004583-199609000-00010
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发表时间：
1996-09-01
影响因子：
13.3
通讯作者：
Ryan, ND
中科院分区：
文献类型：
--
作者：
DeBellis, MD;Dahl, RE;Ryan, ND
目的：检查 38 名身体健康的青春期前重性抑郁儿童与 28 名身体和精神健康的对照儿童的夜间促肾上腺皮质激素、皮质醇、生长激素和催乳素的分泌情况。方法：在采样之前，受试者接受了“适应夜”，并放置了静脉导管和脑电图 (EEG) 电极以进行标准的整夜多导睡眠图。第二天晚上，每 PO 分钟通过留置导管获取血浆样本。通过特定的放射免疫测定法测量激素浓度，并通过脑电图确认的睡眠开始进行调整。计算总分泌量的曲线下面积并使用方差分析进行比较。结果：与对照组相比，青春期前抑郁儿童在入睡后的前 4 小时内皮质醇分泌量较低。促肾上腺皮质激素、催乳素和生长激素的分泌在各组之间没有差异。对抑郁儿童临床特征的检查显示，住院抑郁症患者与门诊抑郁症患者相比，以及遭受性虐待的抑郁症儿童与未受虐待的抑郁症儿童相比，夜间促肾上腺皮质激素浓度较低。显着的性别诊断效应显示，与抑郁男性相比，抑郁女性的生长激素分泌量较低。结论：与这些相同受试者的神经内分泌挑战研究相比，夜间神经内分泌测量没有揭示任何预期的组间差异。这些结果强调了神经内分泌分泌的未刺激研究和挑战研究之间的对比，以及在青春期前抑郁症的生物学研究中考虑临床特征和成熟影响的重要性。
Objective: To examine nocturnal secretion of adrenocorticotropin, cortisol, growth hormone, and prolactin in 38 medically healthy children with prepubertal major depression compared with 28 medically and psychiatrically healthy control children. Method: Prior to sampling, subjects underwent an ''adaptation night'' with the intravenous catheter in place and electroencephalographic (EEG) electrodes for standard all-night polysomnogram. On the following night, plasma samples were obtained every PO minutes through an indwelling catheter. Hormonal concentrations were measured by specific radioimmunoassay and aligned by EEG-confirmed sleep onset. Areas under the curve were calculated for total secretion and compared using analysis of variance. Results: Prepubertal depressed children had lower cortisol secretion during the first 4 hours after sleep onset compared with controls. Adrenocorticotropin, prolactin, and growth hormone secretion did not differ between groups. Examination of clinical characteristics in depressed children revealed lower nocturnal adrenocorticotropin concentrations in depressed inpatients versus depressed outpatients and in depressed sexually abused Versus depressed nonabused children. A significant sex by diagnosis effect revealed lower growth hormone secretion in depressed females compared with depressed males. Conclusions: In contrast to neuroendocrine challenge studies in these same subjects, noctumal neuroendocrine measures did not reveal any of the expected group differences. These results emphasize the contrasts between unstimulated and challenge studies of neuroendocrine secretion and of the importance of considering clinical characteristics and maturation influences in biological studies of prepubertal depression.