Evaluation of surface roughness of hydrogels by fractal texture analysis during swelling.
Evaluation of surface roughness of hydrogels by fractal texture analysis during swelling.
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DOI：
10.1021/la060368v
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发表时间：
2006-05
期刊：
影响因子：
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通讯作者：
G. Mabilleau;M. Baslé;D. Chappard
中科院分区：
文献类型：
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作者：
G. Mabilleau;M. Baslé;D. Chappard
生物材料的表面在与生物流体接触时发生反应。水凝胶用于制备生物材料。材料的表面粗糙度可以通过几种技术来探索。然而，当考虑水凝胶时，在干燥状态下检查的表面不反映最终构象。表面粗糙度如何受到溶胀的影响还很少有定量的研究。我们已经评估了聚（甲基丙烯酸2-羟乙酯）的表面粗糙度（即，pHEMA）。在盐水中孵育不同时间后，在光学显微镜上获得由线性pHEMA制备的圆盘的图像。对图像进行分形纹理分析以确定分形维数D。在该研究中，D在溶胀期间表现出显著降低，并且与溶胀比高度相关（r2 = 0.994，p < 0.00001）。聚合物表面的吸水性影响表面粗糙度。使用分形算法的图像分析似乎是最有趣的技术，无法通过常规方法测量的水合材料的表面的定量探索。
The surface of a biomaterial reacts in contact with biological fluids. Hydrogels are used to prepare biomaterials. The surface roughness of materials can be explored by several techniques. However, when considering hydrogels, the surface examined in the dry state does not reflect the final conformation. How the surface roughness is affected by swelling has been little explored by quantitative methods. We have evaluated the surface roughness of poly(2-hydroxyethyl methacrylate) (i.e., pHEMA) by image analysis. Images of disks, prepared from linear pHEMA, were obtained on a light microscope after various incubation times in saline. Fractal texture analysis was done on images to determine the fractal dimension D. In this study, D exhibited a significant decrease during swelling and was highly correlated with the swelling ratio (r2 = 0.994, p < 0.00001). Water uptake by the surface of the polymer affected the surface roughness. Image analysis using fractal algorithms appears to be the most interesting technique for the quantitative exploration of surfaces of hydrated materials that cannot be measured by conventional methods.