Fragmentation of prostatic needle biopsy cores containing adenocarcinoma: the role of specimen submission
Fragmentation of prostatic needle biopsy cores containing adenocarcinoma: the role of specimen submission
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DOI：
10.1111/j.1464-410x.2009.08737.x
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发表时间：
2010-01-01
影响因子：
4.5
通讯作者：
Epstein, Jonathan I.
中科院分区：
文献类型：
--
作者：
Fajardo, Daniel A.;Epstein, Jonathan I.
目的探讨前列腺癌前列腺核心活检碎片化的原因，这可能使癌核数目和/或核心内肿瘤数量的量化复杂化。材料和方法从作者的咨询服务机构的记录中检索含有碎裂的癌核的前列腺活检病例和仅存在于未碎裂的核心的癌病例。与泌尿科医生提交的特定部位的罐子相对应的‘部分’(即左或右；左尖端、左中端等)。结果未碎片型和碎片型前列腺癌平均每例病灶数分别为8.1个和7.5个，差异无统计学意义。碎片组的平均每部分核心数显著高于未碎片组(2.6vs2.1，P=0.004)。有碎裂核的病例中含有癌症的部分数量高于无碎裂核的病例(2.8vs1.6，P<；0.001)。碎裂核的平均Gleason评分高于未碎裂核(6.6vs6.2，P<；0.001)。多因素回归分析显示，碎片化与癌部位数(P<；0.001)、每部分核心数(P<；0.001)和Gleason评分(P<；0.04)有关。结论每例癌症病例的部分数、每部分提交的核心数和Gleason评分与前列腺癌核心破碎的可能性有关。
OBJECTIVETo determine the factors contributing to the fragmentation of prostatic core biopsies containing prostatic carcinoma, which might complicate the quantification of the number cores with cancer and/or the amount of tumour in a core.MATERIALS AND METHODSProstate biopsy cases containing fragmented cores with cancer and cancer cases present only in unfragmented cores were sought in records from the consultant service of one of the authors. A 'part' corresponded to the site-specific jar submitted by the urologist (i.e. left or right; left apex, left mid, etc.). Cases of prostatic adenocarcinoma with fragmented cores containing cancer (463) and cases with cancer lacking fragmented cores (200) were compared.RESULTSThe mean number of parts per case was 8.1 and 7.5 in the unfragmented and fragmented cases, respectively (not significant). The mean number of cores per part was significantly higher in the fragmented group than the unfragmented group (2.6 vs 2.1, P = 0.004). The number of parts containing cancer was higher in cases with fragmented cores than in cases with unfragmented cores (2.8 vs 1.6, P < 0.001). A higher mean Gleason score was associated with the cancer in fragmented cores than in unfragmented cores (6.6 vs 6.2, P < 0.001). Multivariate regression analysis showed that fragmentation was associated with the number of parts with cancer (P < 0.001), cores per part (P < 0.001) and Gleason score (P < 0.04).CONCLUSIONSThe number of parts per case with cancer, number of cores submitted per part, and Gleason score contribute to the likelihood of fragmentation of cores containing prostatic adenocarcinoma.