The role of mitochondria in the development and progression of lung cancer.
The role of mitochondria in the development and progression of lung cancer.
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DOI：
10.5936/csbj.201303019
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发表时间：
2013
影响因子：
6
通讯作者：
Thomas KJ
中科院分区：
文献类型：
--
作者：
Roberts ER;Thomas KJ
线粒体在人类健康和疾病中的影响是科学文献中迅速扩展的主题，因为它们在细胞死亡和存活中起着不可或缺的作用。线粒体生物学和功能的改变在20世纪20年代随着瓦尔堡效应的发现而首次与癌症联系起来。在ATP合成中利用有氧糖酵解是癌症代谢重编程的许多观察中的第一个。癌症中的线粒体功能障碍已经扩展到包括线粒体基因组学和生物发生、凋亡信号传导和线粒体动力学中的缺陷。本文将重点介绍线粒体的作用及其对肺癌发生、发展和治疗的影响。
The influence of mitochondria in human health and disease is a rapidly expanding topic in the scientific literature due to their integral roles in cellular death and survival. Mitochondrial biology and alterations in function were first linked to cancer in the 1920s with the discovery of the Warburg effect. The utilization of aerobic glycolysis in ATP synthesis was the first of many observations of metabolic reprogramming in cancer. Mitochondrial dysfunction in cancer has expanded to include defects in mitochondrial genomics and biogenesis, apoptotic signaling and mitochondrial dynamics. This review will focus on the role of mitochondria and their influence on cancer initiation, progression and treatment in the lung.