Relationship of glioblastoma multiforme to the subventricular zone is associated with survival
Relationship of glioblastoma multiforme to the subventricular zone is associated with survival
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DOI：
10.1093/neuonc/nos268
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发表时间：
2013-01-01
期刊：
影响因子：
15.9
通讯作者：
Cha, Soonmee
中科院分区：
文献类型：
--
作者：
Jafri, Nazia F.;Clarke, Jennifer L.;Cha, Soonmee
室下区 (SVZ) 位于侧脑室内，代表神经干细胞和一些癌症干细胞的起源。接触 SVZ 的肿瘤可能更具侵袭性，具有更高的招募迁移祖细胞的潜力。我们的具体目的是确定 SVZ 参与多形性胶质母细胞瘤 (GBM) 是否与较高的复发率和较短的总生存期相关。对在我们机构治疗的 91 例 GBM 患者的 MR 成像和临床数据进行回顾性分析。如果术前 MRI 上对比增强病灶同时接触 SVZ 和皮质，则肿瘤被分类为 I 型；如果仅累及 SVZ，则肿瘤被分类为 II 型；如果仅累及皮层，则肿瘤被分类为 III 型；如果病灶不接触 SVZ 或皮层，则肿瘤被分类为 IV 型。根据 Kaplan-Meier 计算估计无进展生存期 (PFS) 和总生存期。将 I 型肿瘤与 II-IV 型肿瘤进行比较时，只有 39% 的 I 型肿瘤患者在 6 个月时没有复发且存活，显着低于所有其他类型肿瘤的总和 (67%；P = .01)。 SVZ 阳性肿瘤患者的 6 个月无进展生存期 (PFS) 也较低，仅为 47%，而 SVZ 阴性组患者的无进展生存期 (PFS) 为 69% (P = .002)。与不累及 SVZ 的患者相比，累及 SVZ 的患者的进展时间也更快 (P = .003)。累及 SVZ 的 GBM 患者的总生存率和 PFS 降低，这可能具有预后和治疗意义。
The subventricular zone (SVZ) lines the lateral ventricles and represents the origin of neural and some cancer stem cells. Tumors contacting the SVZ may be more invasive with higher potential to recruit migratory progenitor cells. Our specific aim was to determine whether SVZ involvement in glioblastoma multiforme (GBM) is associated with a higher recurrence rate and shorter overall survival. MR imaging and clinical data from 91 patients with GBM treated at our institution were retrospectively reviewed. Tumors were classified as type I if the contrast-enhancing lesion contacted both the SVZ and cortex on pre-operative MRI, type II if only the SVZ was involved, type III if only cortex was involved, and type IV if the lesion did not contact either the SVZ or cortex. Progression-free survival (PFS) and overall survival were estimated based on Kaplan-Meier calculations. When comparing type I tumors with types II-IV, only 39% of patients with type I tumors were free of recurrence and alive at 6 months, significantly fewer than for all other types combined (67%; P = .01). PFS at 6 months was also less, at only 47% among patients with SVZ-positive tumors, compared with 69% in the SVZ-negative group (P = .002). Patients with SVZ involvement also demonstrated a more rapid time to progression, compared with those not involving the SVZ (P = .003). Patients with GBM involving the SVZ have decreased overall survival and PFS, which may have prognostic and therapeutic implications.