INVIVO MICROSCOPY OF SCHISTOSOMIASIS .2. MIGRATION OF SCHISTOSOMA-MANSONI IN THE LUNGS, LIVER, AND INTESTINE
INVIVO MICROSCOPY OF SCHISTOSOMIASIS .2. MIGRATION OF SCHISTOSOMA-MANSONI IN THE LUNGS, LIVER, AND INTESTINE
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DOI：
10.4269/ajtmh.1980.29.62
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
BLOCH, EH
中科院分区：
文献类型：
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作者：
BLOCH, EH
体内显微镜被用来研究小鼠曼氏血吸虫血吸虫和虫卵迁移的动力学，试图澄清一些有争议的方面。血吸虫在器官中的迁移仅限于血管系统。幼年血吸虫的迁移是一个被动的过程，盲囊内带色素的血吸虫的迁移是一个主动的过程。在肝脏中，盲囊内有血的血吸虫仅见于门静脉系统的肝内分支。在这些血管中，蠕虫朝着血液流动的方向进食。它们在这些小静脉中的存在不仅干扰了这些血管中的血流，而且干扰了邻近血窦中的血流，导致血窦扩张和囊状，白细胞边缘形成，库普弗细胞中的血色素沉积，最终导致停滞。这会导致周围肝细胞的坏死，其中白细胞和巨噬细胞侵入部位，产生中带坏死。肠壁小静脉内的虫卵多见于直径<60微米的小静脉内。当单个卵子出现在直径几乎等于卵子直径的小静脉中时，血管在这个位置囊状。这样的卵子穿过壁面，没有卵子变形，也没有出血。与单个卵子相比，成串的卵子损害了血液流动，导致壁细胞坏死，并释放了实质中的卵子进行迁移。在实质中，虫卵与肠腔平行，分布于肠壁的各层，绒毛除外，在那里从未发现过虫卵。
In vivo microscopy was used to examine the dynamics of mouse S. mansoni schistosomule and egg migration in an attempt to clarify some of the controversial facets. Schistosomule migration in the organs was restricted to the vascular system. The migration of the youngest schistosomules was a passive process, while the migration of schistosomules with pigment in their ceca was an active one. In the liver, schistosomules with blood in their ceca were only found in the intrahepatic branches of the portal system. In these vessels the worms fed facing the direction of blood flow. The consequences of their presence in these venules were an interference with blood flow not only in these vessels but also in the adjacent sinusoids, which caused dilatation and sacculation of the sinusoids with margination of leukocytes, deposition of blood pigment in Kupffer cells and, finally, stasis. This resulted in necrosis of the surrounding hepatocytes, where leukocytes and macrophages invaded the site producing a midzonal necrosis. Eggs in the mural venules of the intestine were always found in venules with a diameter > 60 .mu.m. When single eggs were present in venules with a diameter almost equal to the diameter of the egg, the vessel sacculated at this site. Such eggs transited through the wall without deformation of the egg and without hemorrhage. In contrast to single eggs, clusters of eggs compromised blood flow, resulting in necrosis of the wall and liberating the eggs in the parenchyma for migration. In the parenchyma, the eggs were parallel to the lumen of the intestine, and were present throughout the various layers of the intestinal wall with the exception of the villi, where they were never found.