Local generation of multineuronal spike sequences in the hippocampal CA1 region
Local generation of multineuronal spike sequences in the hippocampal CA1 region
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DOI：
10.1073/pnas.1508785112
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发表时间：
2015-08-18
影响因子：
11.1
通讯作者：
Buzsaki, Gyoergy
中科院分区：
文献类型：
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作者：
Stark, Eran;Roux, Lisa;Buzsaki, Gyoergy
在海马CA1区的θ波和高频纹波振荡期间，可以观察到多神经元尖峰的顺序活动，这与经验有关，但这种序列的机制尚不清楚。我们比较了自由运动小鼠在θ波振荡、自发波纹和焦光学诱导的高频振荡（“合成”波纹）期间的多神经元尖峰。在θ波振荡、自发波纹和合成波纹中，单个神经元的放电速率和速率调节以及锥体细胞和中间神经元的多神经元序列相互关联。神经元间脉冲对序列一致性至关重要。这些结果表明，单个神经元在群体事件中的参与及其顺序并不是严格由外部输入决定的，而是受到局部回路特性的影响，包括局部神经元之间的突触和单个神经元的生物物理学。
Sequential activity of multineuronal spiking can be observed during theta and high-frequency ripple oscillations in the hippocampal CA1 region and is linked to experience, but the mechanisms underlying such sequences are unknown. We compared multineuronal spiking during theta oscillations, spontaneous ripples, and focal optically induced high-frequency oscillations ("synthetic" ripples) in freely moving mice. Firing rates and rate modulations of individual neurons, and multineuronal sequences of pyramidal cell and interneuron spiking, were correlated during theta oscillations, spontaneous ripples, and synthetic ripples. Interneuron spiking was crucial for sequence consistency. These results suggest that participation of single neurons and their sequential order in population events are not strictly determined by extrinsic inputs but also influenced by local-circuit properties, including synapses between local neurons and single-neuron biophysics.