Compact movable microwire array for long-term chronic unit recording in cerebral cortex of primates
Compact movable microwire array for long-term chronic unit recording in cerebral cortex of primates
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DOI：
10.1152/jn.00569.2007
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发表时间：
2007-11-01
影响因子：
2.5
通讯作者：
Fetz, Eberhard E.
中科院分区：
文献类型：
--
作者：
Jackson, Andrew;Fetz, Eberhard E.
我们描述了一种小型的、可长期植入的微线阵列，用于从不受限制的非人类灵长类动物的大脑皮层获得长期的单位记录。植入后，微丝的深度可以单独调整，以保持单个神经元数月来的大幅度动作电位记录。我们提供了两只猴子的初级运动皮质的数据，这些数据是由自主机载电子电路记录的。在不受限制的行为中，单个神经元的波形在几周的记录期内保持稳定。信噪比、波形稳定性和细胞损失率表明，这种方法可能特别适合于研究持续多天的过程的神经相关性的实验，如学习和可塑性。
We describe a small, chronically implantable microwire array for obtaining long-term unit recordings from the cortex of unrestrained nonhuman primates. After implantation, the depth of microwires can be individually adjusted to maintain large-amplitude action potential recordings from single neurons over many months. We present data recorded from the primary motor cortex of two monkeys by autonomous on-board electronic circuitry. Waveforms of individual neurons remained stable for recording periods of several weeks during unrestrained behavior. Signal-to-noise ratios, waveform stability, and rates of cell loss indicate that this method may be particularly suited to experiments investigating the neural correlates of processes extending over multiple days, such as learning and plasticity.