Comorbidity was associated with neurologic and psychiatric diseases: A general practice-based controlled study
Comorbidity was associated with neurologic and psychiatric diseases: A general practice-based controlled study
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DOI：
10.1016/j.jclinepi.2006.01.005
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发表时间：
2006-12-01
影响因子：
7.2
通讯作者：
Groenewegen, Peter P.
中科院分区：
文献类型：
--
作者：
Nuyen, Jasper;Schellevis, Francois G.;Groenewegen, Peter P.
背景和目的：全面研究抑郁症、中风、多发性硬化症(MS)、帕金森氏病/帕金森综合症(PD/PKM)、痴呆、偏头痛和癫痫患者的共病情况。指标疾病队列大小从241名多发性硬化症患者到6641名终生抑郁症患者。通过与年龄和性别匹配的对照队列进行比较，检查了30种躯体疾病和7种精神疾病类别，以确定它们是否与指标疾病共存。已识别的合并症被归类为“可能”或“极有可能”的合并症。结果：广泛的26种疾病类别被发现与终生抑郁症并存。中风的共病范围也很广，包括21个疾病类别。偏头痛和癫痫的共病模式分别包括11种疾病类别。结论：本研究全面了解了抑郁症、卒中、MS、PD/PKM、痴呆、偏头痛和癫痫患者的躯体和精神共病的发生情况。讨论了这些发现对临床实践和研究的意义。(C)2006 Elsevier Inc.保留所有权利。
Background and Objective: To comprehensively examine comorbidity in unselected cohorts of patients with depression, stroke, multiple sclerosis (MS), Parkinson's disease/parkinsonism (PD/PKM), dementia, migraine, and epilepsy.Methods: This cross-sectional study used morbidity data recorded by Dutch general practitioners. Index disease cohort sizes ranged from 241 patients with MS to 6,641 patients with lifetime depression. Thirty somatic and seven psychiatric disease categories were examined to determine whether they were comorbid with the index diseases by performing comparisons with age- and gender-matched control cohorts. Identified comorbidities were classified as either "possible" or "highly probable" comorbidity.Results: An extensive range of 26 disease categories was found to be comorbid with lifetime depression. The comorbidity profile of stroke was also wide, including 21 disease categories. The comorbidity patterns of migraine and epilepsy comprised each 11 disease categories. Those concerning MS, PD/PKM, and dementia included a small number of disease categories.Conclusion: This study provides comprehensive knowledge of the occurrence of somatic and psychiatric comorbidity in general populations of patients with depression, stroke, MS, PD/PKM, dementia, migraine, and epilepsy. The implications of the findings for clinical practice and research are discussed. (C) 2006 Elsevier Inc. All rights reserved.