Hepatitis C virus and autophagy.
Hepatitis C virus and autophagy.
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DOI：
10.1515/hsz-2015-0172
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发表时间：
2015-11
影响因子：
3.7
通讯作者：
Ou JH
中科院分区：
文献类型：
--
作者：
Wang L;Ou JH
Autophagy is a catabolic process by which cells remove protein aggregates and damaged organelles for recycling. It can also be used by cells to remove intracellular microbial pathogens including viruses in a process known as xenophagy. However, many viruses have developed mechanisms to subvert this intracellular antiviral response and even use this pathway to support their own replications. Hepatitis C virus (HCV) is one such virus. HCV is an important human pathogen that can cause severe liver diseases. Recent studies indicated that HCV could activate the autophagic pathway to support its replication. This review summarizes the current knowledge on the interplay between HCV and autophagy and how this interplay affects HCV replication and host innate immune responses.
