Nosocomial outbreak of COVID-19 pneumonia in Wuhan, China
Nosocomial outbreak of COVID-19 pneumonia in Wuhan, China
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中国武汉市院内爆发 COVID-19 肺炎
DOI：
10.1183/13993003.00544-2020
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发表时间：
2020-06-01
影响因子：
24.3
通讯作者：
Gao, Zhancheng
中科院分区：
文献类型：
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作者：
Wang, Xiaorong;Zhou, Qiong;Gao, Zhancheng
2020年初，新型冠状病毒——严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）在中国感染了3300多名医护人员。关于最初时期卫生保健工作者医院感染的信息知之甚少。我们分析了武汉协和医院医院感染的医护人员及其家属的数据。方法收集并分析2020年1月5日至2月12日期间实验室确诊2019冠状病毒病（COVID-19）的25名卫生保健工作者和2名高度疑似COVID-19的卫生保健工作者及其10名感染COVID-19的家庭成员的暴露史、发病时间线和流行病学特征数据。对35例实验室确诊病例的人口统计学和临床特征进行了调查，并对12例病例的病毒RNA进行了测序和分析。结果患者中共发现9个聚类。所有患者均有轻至中度临床表现，康复无恶化。平均潜伏期为4.5 d，平均±sd临床发病序列间隔（COSI）为5.2±3.2 d，中位病毒脱落时间为18.5 d。对12种不同冠状病毒株的全基因组序列分析表明，该病毒结构在传播链中是稳定的，具有明显的传染性可追溯性。结论基于潜伏期短和COSI， SARS-CoV-2在医院环境和社会活动中，无论是否有症状，都可以在人与人之间快速传播。公共卫生部门应采取切实措施，包括隔离病例、追踪密切接触者、封锁严重疫区等，遏制疫情蔓延。此外，医护人员在疫情期间应提高警惕，如果自我怀疑感染，应自我隔离。SARS-CoV-2可以在医院和社会环境中迅速在人与人之间传播，尽管患者没有症状https://bit.ly/34BHtB5
Background The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infected over 3300 healthcare workers in early 2020 in China. Little information is known about nosocomial infections of healthcare workers in the initial period. We analysed data from healthcare workers with nosocomial infections in Wuhan Union Hospital (Wuhan, China) and their family members. Methods We collected and analysed data on exposure history, illness timelines and epidemiological characteristics from 25 healthcare workers with laboratory-confirmed coronavirus disease 2019 (COVID-19) and two healthcare workers in whom COVID-19 was highly suspected, as well as 10 of their family members with COVID-19, between 5 January and 12 February 2020. The demographics and clinical features of the 35 laboratory-confirmed cases were investigated and viral RNA of 12 cases was sequenced and analysed. Results Nine clusters were found among the patients. All patients showed mild to moderate clinical manifestation and recovered without deterioration. The mean period of incubation was 4.5 days, the mean±sd clinical onset serial interval (COSI) was 5.2±3.2 days, and the median virus shedding time was 18.5 days. Complete genomic sequences of 12 different coronavirus strains demonstrated that the viral structure, with small irrelevant mutations, was stable in the transmission chains and showed remarkable traits of infectious traceability. Conclusions SARS-CoV-2 can be rapidly transmitted from person to person, regardless of whether they have symptoms, in both hospital settings and social activities, based on the short period of incubation and COSI. The public health service should take practical measures to curb the spread, including isolation of cases, tracing close contacts, and containment of severe epidemic areas. Besides this, healthcare workers should be alert during the epidemic and self-quarantine if self-suspected of infection. SARS-CoV-2 can be rapidly transmitted from person to person in nosocomial and social settings, despite patients having no symptoms https://bit.ly/34BHtB5