Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants
Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants
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DOI：
10.1136/fn.88.6.f501
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发表时间：
2003-11-01
影响因子：
4.4
通讯作者：
Dembinski, J
中科院分区：
文献类型：
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作者：
Heep, A;Behrendt, D;Dembinski, J
背景：早产儿脑室内出血（IVH）和脑室周围白质软化症（PVL）可能有多种原因。目的：探讨胎龄< 28周早产儿产后血清白细胞介素6（IL 6）水平与新生儿脑损伤的相关性。方法：采用免疫组织化学方法检测胎龄< 28周早产儿产后血清IL 6水平，并与新生儿脑损伤发生率进行相关性分析。根据产后12小时内最大血清IL 6水平将总共88名婴儿分组：A组（n = 50），100 pg/ml。结果：IVH在B组（24/38; 63%）明显多于A组（19/50; 38%）（p = 0.02）。在多元逻辑回归模型中，血清IL 6升高独立预测严重IVH的发展（比值比8.4; 95%置信区间2.85至24.9; p = 0.0001）。结论：血清IL 6升高可作为胎龄< 28周婴儿严重IVH的标志物。虽然早产儿的脑发病率是由不同的变量决定的，但全身炎症的识别有助于确定预防脑发病的抗炎策略的必要性。
Background: Intraventricular haemorrhage (IVH) and periventricular leucomalacia (PVL) in premature infants presumably have many causes. It has been proposed that inflammatory processes in the fetomaternal unit play an important role in the pathogenesis of these lesions.Objective: To study the correlation of postpartum serum interleukin 6 (IL6) concentration as a marker of inflammation and neonatal cerebral morbidity in preterm infants < 28 weeks of gestational age.Methods: A total of 88 infants were grouped according to maximum serum IL6 levels within 12 hours post partum: group A (n = 50), 100 pg/ml. Ultrasound studies and clinical assessment were performed routinely.Results: IVH was noted significantly more often in group B (24/38; 63%) than in group A (19/50; 38%) (p = 0.02). In a multiple logistic regression model, raised serum IL6 independently predicted development of severe IVH (odds ratio 8.4; 95% confidence interval 2.85 to 24.9; p = 0.0001).Conclusions: Raised serum IL6 may serve as a marker for severe IVH in infants < 28 weeks of gestational age. Although cerebral morbidity in premature infants is determined by different variables, the identification of systemic inflammation can help to define the need for anti-inflammatory strategies to prevent cerebral morbidity.