Mechanisms of Subcutaneous and updates Sublingual Aeroallergen Immunotherapy: What Is New?
Mechanisms of Subcutaneous and updates Sublingual Aeroallergen Immunotherapy: What Is New?
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DOI：
10.1016/j.iac.2019.09.009
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发表时间：
2020-02-01
影响因子：
2.6
通讯作者：
Akdis, Cezmi A.
中科院分区：
文献类型：
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作者：
Komlosi, Zsolt Istvan;Kovacs, Nora;Akdis, Cezmi A.
过敏原免疫疗法（AIT）被认为是唯一的治疗选择，有希望治愈和诱导持久的过敏原耐受性，即使在停止治疗后也会持续存在。尽管有100多年的历史，但仍然只有少数患者接受AIT治疗。在过去十年中，在克服标准化、有效性、安全性、高成本、治疗持续时间长等问题方面取得了重大进展;还实施了新的指导方针。主要进展的认识AIT机制的重点是最近的研究结果皮下和舌下AIT进行了总结。
Allergen immunotherapy (AIT) is considered to be the only treatment option with the promise of healing and induction of long-lasting allergen tolerance, persisting even after discontinuation of therapy. Despite a more than 100-year-long history, still only a minority of patients are being treated with AIT. Substantial developments took place in the last decade to overcome problems in standardization, efficacy, safety, high costs, long duration of treatment; and new guidelines have also been implemented. Major advancements in the understanding of AIT mechanisms with the focus on recent findings of subcutaneous and sublingual AIT have been summarized.